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Yichang Sanxia Pharmaceutical Co., Ltd.

25 YRS

Hubei, China

CNY 390 Million

169830 m²

Over 1000 people

Main Products: Neomycin Sulfate

Hubei, China

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Neomycin Sulfate (EP Standard) / CAS 1405-10-3

OVERVIEW

Packaging

25 KG/Fibre Drum

Lead Time

14-30 days

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DESCRIPTION

Neomycin sulfate

English Name: neomycin sulfate

CAS No.: 1405-10-3

Molecular formula: C23H48N6O17S

Molecular weight: 712.72

EINECS No.: 215-773-1

Melting point: > 187 ° C (Dec.)

Specific rotation: D20 + 54 ° (C = 2 in H2O)

Refractive index: 56 ° (C = 10, H2O)

Flash point: 56 ℃

Introduction: neomycin sulfate is an aminoglycoside antibiotic. The product has good antibacterial effect on Staphylococcus (methicillin sensitive strain), Corynebacterium, Escherichia coli, Klebsiella, Proteus and other Enterobacteriaceae, but has poor activity on Streptococcus, Streptococcus pneumoniae and Enterococcus. Pseudomonas aeruginosa and anaerobic bacteria are resistant to this product. Bacteria have partial or complete cross resistance to streptomycin, neomycin, kanamycin and gentamicin.

Application: it is used to prevent and cure diarrhea, dysplasia and other diseases of pigs, chickens, cattle and other livestock and poultry caused by Escherichia coli and Salmonella. It can also be used to treat enteritis of fish and shrimp in aquatic products

Typical Properties

Neomycin Sulfate is the sulfate salt form of neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, neomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.

CAS No.

1405-10-3

Formula

C23H48N6O17S

Molecular Mass

712.722

Exact Mass

712.28

PSA

436.09000

Logp

-4.26550

IUPAC

(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid

SMILES

C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O

Matter Classification

organic

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