Ergothioneine/L-Ergothioneine/L-Ergothioneine Powder For Skin / CAS 497-30-3

CAS 497-30-3 High Purity 99% L-Ergothioneine ERGO/EGT for Cosmetic

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Supply Ability

0.1 Metric Tons/Year( After the new plant is put into operation, the annual output can reach 5 ~ 10 tons)

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Specification of L-Ergothioneine (EGT) (CAS 497-30-3)

Shenzhen Readline Biotech Ltd

Shenzhen Readline Biotech Co., Ltd. is a professional L-ergothioneine manufacturer. Founded in 2017, it is an innovative high-tech enterprise with synthetic biotechnology as the core and multidisciplinary application. The world takes the lead in applying synthetic biotechnology to the full green commercial production of "life molecules", and promotes "carbon neutrality" and "carbon emission reduction" in the field of characteristic functional raw materials. Its product applications cover biomedicine, nutrition and health, medical beauty Daily chemical, animal health, green agriculture and biological materials and other fields.

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Description of L-Ergothioneine (EGT) (CAS 497-30-3)

L-Ergothioneine is a rare natural chiral amino acid derivative.

In 1909, Charles Tanret, while studying the ergot fungus that destroys rye grains, isolated a unique crystalline sulfur-containing compound, and subsequently named this water-soluble thiol l-ergothioneine after the ergot fungus.

In the dissolved state, l-ergothioneine exists in the form of tautomer between its two structures, thione and thiol; while at physiological pH, l-ergothioneine mainly exists in the form of thione, so it will only react with some sulfhydryl reagents. Additionally, the standard redox potential of thiol-disulfides is 0.06 volts, while the redox potentials of other natural thiols are typically between 0.2 and 0.32 volts. Taken together, these two unique properties confer greater stability to l-ergothioneine under physiological conditions, making it less prone to auto-oxidative reactions than other antioxidant thiols such as glutathione.

Efficacy and Mechanism of L-Ergothioneine (EGT) (CAS 497-30-3)

① OCTN1 Transporter

The operation of l-ergothioneine in organisms depends on a special transporter OCTN1 (organic cation transporter N1, product of the SLC22A4 gene), OCTN1 exists in keratinocytes and melanocytes and has a high affinity for ergothioneine, so skin tissue and cells can easily accept, absorb, and fully utilize l-ergothioneine. Through OCTN1 existing on the cell membrane and mitochondrial membrane, l-ergothioneine is transported to the main "foci" of free radical production in cells - mitochondria, protecting mitochondria from oxidative damage and directly scavenging active oxygen free radicals to achieve delay in the human body. The ultimate goal of cellular aging.

② Antioxidant

Fibroblasts are the most common cells in connective tissue, with vigorous functional activities and can secrete structural proteins that constitute the extracellular matrix, which are closely related to the aging process of the skin. L-Ergothioneine protects human fibroblasts and enhances their viability by reducing the degradation of matrix metalloproteinase-1 (MMP-1) and increasing the production of type I collagen; inhibits UVA-induced reactive oxygen species in fibroblasts Free radical production, activation of transcription factor AP-1; simultaneous upregulation of Nrf2 factor (a basic leucine zipper protein that acts as a transmitter of oxidative and electrophilic stress responses and inhibits genomic instability) in fibroblasts The nuclear translocation of Nrf2 induces antioxidant gene expression and glutathione production in UVA-irradiated fibroblasts. Glutathione is an abundant non-protein thiol in cells and acts as an antioxidant to protect cells from reactive oxygen species free radicals, and the effect of l-ergothioneine on glutathione levels in fibroblasts means that it is not just a A potent antioxidant and a powerful antioxidant inducer.

③ Anti-inflammatory and other chronic diseases

L-Ergothioneine has been shown to inhibit NFkβ (nuclear transcription factor kβ) activation and UVB irradiation-induced upregulation of TNF-α (tumor necrosis factor-α); prevent TNF-α-mediated inflammatory cells in epithelial cells Activation and increase the factors IL-8 (interleukin-8) and IL-6 (interleukin-6); and by activating the p38 and JNK signaling pathways to prevent cell death caused by free fatty acids, thereby resisting inflammation and even efficacy in chronic diseases.

Our Advantages of L-Ergothioneine (EGT) (CAS 497-30-3)

Readline conducts large-scale production of L-Ergothioneine with the most promising synthetic biotechnology at present, which has obvious advantages such as simple source of raw materials, mild reaction conditions and strong specificity. This technology is not only very friendly to environmental protection, but also achieves the advantage of large-scale production cost under the premise of realizing all-green production. The product has high purity, fewer impurities, good color, and no irritating odor. It is healthier for food or skin care products. safer.

As one of the company's star products, Readline's L-Ergothioneine successfully won the 17th Ringier 2021 on July 14, 2021, with its overwhelming advantages such as technological innovation, stable quality, safety and no residue, and green environmental protection. Technology Innovation Award in the Functional Ingredients category for the Personal Care Industry.

Keywords

Ergothioneine CAS 497-30-3; L-Ergothioneine CAS 497-30-3; L-(+)-Ergothioneine; Thiasine; Sympectothion; Ergothioneine EGT Supplier; China Ergothioneine EGT Manufacturer; L-Ergothioneine Manufacturer; L-Ergothioneine Suppliers; L Ergothioneine In Cosmetics; L-Ergothioneine Powder; EGT Ergothioneine For Skin; 99% L-Ergothioneine.

FAQ of Shenzhen Readline Biotech Ltd

Q1. Why choose us?

① Our company uses the most promising synthetic biotechnology for large-scale production of l-ergothioneine, which has obvious advantages such as simple source of raw materials, mild reaction conditions and strong specificity. At the same time, our l-ergothioneine won the 17th Ringier 2021 Technology Innovation Award in the category of functional ingredients in the personal care industry with an overwhelming advantage on July 14, 2021.

② We have successively obtained ISO9001:2015 quality management system certification, intellectual property management system certification, IFRC Halal certification, EFfCl GMP certification, Kosher Jewish certification and FDA cGMP, FSSC 22000 certification and many other authoritative certifications at home and abroad, and obtained the national high-tech enterprise Certification and the title of top 30 enterprises in the field of medical and health care in Shenzhen.

③ Our R&D team accounts for 60%, the master's degree or above accounts for nearly 50%, and 12% of the entrepreneurs have overseas study or work experience.

Q2. What are your payment terms?

TT, LC, OA, and DA, all the payments are optional, with the support of Chemball.

Q3. Is it possible to customize the labels with our own design?

Yes, please contact us if you have any special requests, you will get what you want.

Q4. Are you able to deliver on time?

Of course! We specialized in this line for many years, many customers make a deal with me because we can deliver the goods on time and keep the goods top quality!

Q5. We don’t know you at all, how can we trust you?

You are always warmly welcome to visit us at any time. Before we start B2B, Chemball has audited our company and approved our credit. Commitment is the No.1 Point of our Enterprise’s Value.

Q6. How to contact us?

Contact us by Chemball page, email, mobile phone, any way you like! We will try our best to respond ASAP!