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Changshu Nanhu Industrial Chemical Co., Ltd.
Changshu Nanhu Industrial Chemical Co., Ltd.
31 YRS
Jiangsu, China
Main Products:
Sulfadoxine / 4,6-Dichloro-5-Methoxypyrimidine / 4-Amino-N-(6-Chloro-5-Methoxypyrimidin-4-Yl)Benzene-1-Sulfonamide / Primaquine Diphosphate
Jiangsu, China
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Primaquine Diphosphate / CAS 63-45-6
OVERVIEW
Packaging
25 KG/Fibre Drum; 10 KG/Fibre Drum; 5 KG/Fibre Drum
Lead Time
14-30 days
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DESCRIPTION
Primaquine Diphosphate
Molecular formula: | C15H21N3O |
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Molecular weight: | 259.35 | |
Structural formula: |
| |
CAS NO： | 63-45-6 | |
Product standard: | BP98、USP24 | |
Usage: | Antimalarial. | |
Storage requirement: | Avoid light, seal preservation | |
Packing: | 25kg., 10kg., 5kg., fiber can, with polyethylene plastic bags in it. | |
Typical Properties
Summary
This product belongs to 8-aminoquinoline derivatives. It has strong killing effect on the infrared phase and gametophyte of Plasmodium. It is an effective drug to prevent recurrence and interrupt transmission. The antimalarial mechanism may be the interference of DNA synthesis of Plasmodium. Plasmodium must provide some enzymes or coenzymes for pentose phosphate pathway metabolism in the infrared phase by human liver cells. Due to the hydroxylation of primaquine, a large number of hydrogen donors from liver cells are consumed, resulting in the lack of enzymes or coenzymes used by Plasmodium, resulting in the death of Plasmodium in the infrared phase. This product can kill Plasmodium vivax, Plasmodium vivax, Plasmodium falciparum and Plasmodium ovale in the infrared phase schizonts. The best effect is to kill Plasmodium vivax. It can also kill gametophytes of various Plasmodium species. It has the strongest effect on Plasmodium falciparum, but has very weak effect on erythrocytic schizonts.
CAS No.
63-45-6
Formula
C15H27N3O9P2
Molecular Mass
455.33700
Exact Mass
455.12200
PSA
235.31000
Logp
1.69880
IUPAC
4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine;phosphoric acid
SMILES
CC(CCCN)NC1=C2C(=CC(=C1)OC)C=CC=N2
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Antiparasitic Drugs
Chemical and Physical Properties
Melting Point
205-206 °C (dec.)(lit.)
Boiling Point
451.1ºC
Flash Point
226.6 ºC
Appearance
Orange powder
Export information
HS Code
29334900
Export Rebate
13%
UN No.
2811
DG-Class
6.1(b)
Risk Code
R25
Safety Label
T
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