2-Aminopyridine

CAS：504-29-0

Molecular formula：C5H6N2

Molecular weight：94.11

Structure：

Physicochemical properties: Colorless leaf like or large crystal. Melting point 57-58 ℃, boiling point 204 ℃, 104-106 ℃ (2.67kpa), flash point 92 ℃. Soluble in water, alcohol, benzene, ether and hot petroleum ether. It tastes bitter and has anesthetic effect. Can sublimate.

Uses: In the field of medicine, as an important pharmaceutical intermediate, 2-aminopyridine can be condensed and hydrolyzed to obtain sulfanilamide antibacterial drug pyridine sulfonamide. Sulfasalazine was prepared by coupling sulfasalazine with salicylic acid after diazotization and acidification. Sulfasalazine is a kind of sulfonamide that is not easy to be absorbed orally. It is hydrolyzed into 5-aminosalicylic acid and SULFAPYRIDINE through intestinal microbial absorption. In addition, 2-aminopyridine is also used to synthesize analgesic and anti-inflammatory drugs piroxicam and lornoxicam, and to alleviate the symptoms of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.

It is used as analytical reagent, microcrystalline analysis and organic synthesis.

Organic synthesis, intermediates and chemical reagents of drugs and dyes. Intermediates of organic synthesis are used as analytical reagents, and microcrystalline analysis and organic synthesis are used to test antimony, bismuth, cobalt, copper, gold and zinc.