Oxolinic acid

Product introduction:

Oxolinic acid is a second-generation quinolone bactericide. It has strong antibacterial effect on Gram-negative bacteria and some positive bacteria, and has no cross resistance to antibiotics. However, it has no antibacterial effect on fungi and Mycobacterium tuberculosis. It has the advantages of low dosage and good antibacterial effect. It is mainly used to treat bacterial diseases of fish and shrimp, Aquaculturists believe that it is one of the ideal drugs for the treatment of aquatic animal diseases. It has strong antibacterial activity against fish pathogens such as Vibrio anguillarum and Aeromonas hydrophila.

Quality standard: CPV99/EP6.5

Pharmacological action:

For agriculture:

Quinolinone fungicides have a wide range of antibacterial activity against Gram-negative function, but have weak activity against Gram-positive bacteria and no activity against fungi. By inhibiting the synthesis of DNA, it hinders the division and proliferation of bacteria. In the bacterial cell, the reverse super curl enzyme is introduced into the super curl structure of DNA. This agent can combine with subgroup A of this enzyme, so that its function is suppressed, so that DNA can not replicate, and soon cause death.

For aquatic products:

This product belongs to the first generation of quinolones, and its action mechanism is to inhibit the synthesis of bacterial deoxynucleotides. It has strong antibacterial effect on Gram-negative bacteria, but has no antibacterial effect on fungi and Mycobacterium tuberculosis. It has strong antibacterial activity against fish pathogens such as Aeromonas salmon, Aeromonas hydrophila and Vibrio anguillarum, and its mic50 is 0.02 ~ 0.09 μ g/ml。 After oral administration of 5mg / kg, 10mg / kg, 20mg / kg and 40mg / kg to carp, the blood drug concentration appeared the highest value after 15 ~ 24h, and the blood drug concentration remained at 0.2 μ 66h above g / ml. The toxicity of this product is very slight. In the acute toxicity test, the oral LD50 for carp is more than 4000 mg / kg.

Indication:

For agriculture:

This product can be used as a special agricultural medicine and has excellent therapeutic effect on rice leaf blight and seedling rot. Used for rice seed treatment, it is called the first bactericide with excellent effect on the refractory disease of rice, grain blight bacterial disease (seedling corruption). Seed dressing before sowing can inhibit the occurrence of broken seedling corruption caused by grain blight bacterial disease, and then the occurrence of grain blight bacterial disease can be prevented after transplanting robust seedlings.

For aquatic products:

It can be used to prevent and control sarcoidosis of catfish, sea bream, bamboo pod fish and tilapia, furuncle disease and Vibrio disease of silver salmon, trout, rose salmon, bacterial sepsis and enteritis of Cyprinidae, intestinal sepsis of channel catfish, red fin disease and red spot disease of eel, Vibrio disease of shrimp in Japan, Aeromonas infection of fragrant fish, etc.

Usage and dosage:

Agriculture:

Soaking seeds at 1000g / ml for 24h, soaking seeds at 1000g / ml for 10min, or coating seeds with 20% wettable powder at 0.5% of seed mass, the control effect is more than 97%. This product can also be used to control rice grain rot, potato black cavity disease, soft rot, fire blight and similar diseases. If 300 ~ 600g active ingredient / hm2 was sprayed on the leaves at heading stage, rice grain rot could be controlled; Spraying 300 ~ 600g active ingredient / hm2 on the leaves can control fire blight and soft rot of apple and pear. It also has a good protective and therapeutic effect on Chinese cabbage soft rot.

Aquatic products:

made into preparations.

① Oral administration for the treatment of trout furuncle disease, Vibrio disease, Aeromonas infection of fragrant fish and red fin disease of eel, 5 ~ 20mg / kg body weight per day, fed twice for 5 ~ 7d; Furuncle like disease, 10 ~ 30mg / kg body weight per day, fed twice for 5 ~ 7 days; Eel red spot disease, 1 ~ 5mg / kg body weight per day, fed twice for 3 ~ 5 days. The drug withdrawal period is 2D for oyster, 5D for trout, 3D for fragrant fish, 4D for carp and 18D for eel.

② Soak in the bath to make the oral oxaquinic acid concentration in the water body reach 3 ~ 5mg / L, 2 ~ 4H each time, once a day, and use it for 2 ~ 3 times.