Linaelotide Acetate / Argpessin / CAS 851199-59-2

Highlights of Holypharm Linaclotide Powder:

▶ Quality: Linaclotide is produced by the biosynthesis process, without residual solvent, and with high purity.

▶ Strong supply capacity: Compared with chemical synthesis, the production capacity of the biological synthesis process is not limited. The capacity of each batch can reach the kilogram level.

▶ The lower price: The price of Linaclotide is 5%~10% lower than that of our competitors.

Quick Details

Supply Ability

40 KG per Year

Packaging & Delivery

Specifications of Linaelotide Acetate / Linaclotide Powder CAS 851199-59-2

Profile of Holypharm Biotech

Holypharm Biotech is a company that uses the latest biosynthetic technology to produce the latest international cosmetics raw materials, nutritional ingredients, and preparations. The company is co-founded by business elites and brilliant scientists with strong academic backgrounds. We use synthetic bio-engineering technologies to provide innovative manufacturing solutions.

Through systematic engineering at the level of molecular (DNA manipulation, direct evolution of enzymes, etc.), cellular and sub-cellular (metabolic network rewriting and compartmentalization), and culturing (fermentation optimization), we manage to commercialize our designed microbial cell factories for large-scale bio-manufacturing of various products.

CRAM of Holypharm Biotech

Supported by our professional expert team and outstanding GMP system, Holypharm offers Contract Research and Manufacturing (CRAM) services for active pharmaceutical ingredients (APIs) from synthesis and fermentation that cover all therapeutic areas.

Two solutions for our CRAM Services:

1. Produce APIs according to the dossier provided by customers.

2. Develop and optimize the manufacturing process from lab to commercial when a customer has limited techniques on target products.

We here guarantee that any inquiries from our customers and all projects undertaken by Holypharm will be kept confidential or protected by nondisclosure agreements if it is necessary.

Why Choose Holypharm Biotech?

▶ We have our GMP standard plants in Jiangsu and Zhejiang provinces, and 68 researchers in the R&D center in Wuhan and Tianjin. Moreover, we also have a close relationship with labs from the top 10 Chinese research institutes.

▶ We have expanded our business worldwide covering the major pharmaceutical markets, especially US and EU where our representative offices are located. Attributing to the efforts of our regulatory affairs (RA) experts, we are participating in the registration of several promising APIs in the US and EU as well as cooperating with Novartis, CHEMO, and Merck.

▶ We hold the gold relationship with both domestic and foreign pharmaceutical manufacturers, we are adept in re-arranging and co-ordinating their supply and demand on formulations to build up an excellent pipeline system that will benefit all the worldwide healthcare welfare.

Introduction of Linaelotide Acetate / Linaclotide Powder CAS 851199-59-2

Linaclotide, also known as Linaelotide acetate under the trade name Linzess, is a guanylate cyclase-C receptor agonist (GCCA) with both visceral analgesic effects and endocrine activity.

Linaclotide and its active metabolites can both bind to guanylate cyclase-C (GC-C) receptors on the luminal surface of the small intestinal epithelium. Through the activation of GC-C, intracellular and extracellular cGMP (cyclic guanylate) concentrations rise. Extracellular cGMP, which reduces the activity of pain nerve fibers, reduces visceral pain in model animals. Intracellular cGMP can increase the amount of chloride and bicarbonate secretion in the small intestinal lumen by activating CFTR (cystic fibrosis transmembrane conductance regulator), ultimately leading to increased small intestinal fluid secretion and faster small intestinal transit.

Applications of Linaelotide Acetate / Linaclotide Powder CAS 851199-59-2

Linaclotide, also known as Linaelotide acetate under the trade name Linzess, is a 14 amino acid synthetic peptide structurally related to the endogenous guanosine peptide family and is the only FDA-approved GC-C (guanylate cyclase-C) agonist class of drugs with local onset in the gut that can be used clinically to treat adult patients with constipation-predominant irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC).

Advantages of Linaelotide Acetate / Linaclotide Powder CAS 851199-59-2

▶ Quality: Linaclotide is produced by the biosynthesis process, without residual solvent, and with high purity.

▶ Strong supply capacity: Compared with chemical synthesis, the production capacity of the biological synthesis process is not limited. The capacity of each batch can reach the kilogram level.

▶ The lower price: The price of Linaclotide is 5%~10% lower than that of our competitors.

Production Process of Linaelotide Acetate / Linaclotide Powder CAS 851199-59-2

There are two kinds of production processes on the market: chemical synthesis and biosynthesis.

Holypharm Biotech uses biosynthesis to produce Linaclotide which compared with chemical synthesis, the production capacity of the biological synthesis process is not limited, without residual solvent, and with high purity.

Keywords Related to Linaelotide Acetate / Linaclotide Powder CAS 851199-59-2

Linaclotide Powder Pharmaceutical Peptides; Linaelotide Acetate CAS 851199-59-2; Peptide Raw Linaelotide Acetate Powder; Argpessin / Linzess Powder Manufacturer

FAQ of Holypharm Biotech

Q1. Are you a manufacturer or trading company?

We are a manufacturer that owns GMP factories both in Jiangsu and Zhejiang Province. They cover an area of about 2000 mu. You are warmly welcome to visit us!

Q2. What are your payment terms and types?

TT, LC, OA, and DA, all the payments are optional, with the support of Chemball.

Payment Type: L/C, T/T, D/P, OA, Paypal, Western Union.

Q3. We don’t know you at all, how can we trust you?

You are always warmly welcome to visit us at any time. Before we start B2B, Chemball audited our company and approved our credit. Commitment is the No.1 Point of our Enterprise’s Value.

Q4. How to contact us?

Contact us by Chemball page, email, mobile phone, or any way you like! We will try our best to respond ASAP!