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Shandong Xingshun New Material Co.,Ltd.
Shandong Xingshun New Material Co.,Ltd.
28 YRS
Shandong, China
Main Products:
1-Acetonaphthone / 4-Vinylbenzyl Chloride / Vinylbenzyl Chloride / 1-Chloromethyl Naphthalene / 1-Methyl-Aminomethyl Naphthalene / 6-Bromo-2-Naphthoic Acid / 4-Bromo Phthalic Anhydride
Shandong, China
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6-Bromo-2-Naphthoic Acid / CAS 5773-80-8
OVERVIEW
Uses
Packaging
25 KG/Woven Bag
Lead Time
14-30 days
Max Capacity
10 MT/Year
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DESCRIPTION
6-Bromo-2-Naphthoic Acid
Product name | 6-Bromo-2-naphthoic acid |
Product Category | Naphthalene series |
CAS NO. | 5773-80-8 |
Structural formula |
|
Typical Properties
Summary
6-bromo-2-naphthoic acid can be used as an intermediate in pharmaceutical synthesis. For example, adapalene, a derivative of naphthoic acid, belongs to the third generation of retinoic acid drugs. Its chemical name is 6 - [3 - (1-adamantyl) - 4-methoxyphenyl] - 2-naphthoic acid. It is an anti acne drug developed by France's gaudemai pharmaceutical company. Adapalene is a retinol compound that binds to the specific nuclear retinoic acid receptor like all trans retinoic acid, But the difference is that it can selectively bind to retinoic acid receptors related to keratinocyte proliferation and differentiation γ， It does not bind to cytoplasmic retinoic acid binding protein. Its mechanism is mainly to reduce the formation of micro acne by regulating the differentiation of hair follicle epithelial cells.
CAS No.
5773-80-8
Formula
C11H7BrO2
Molecular Mass
251.07600
Exact Mass
249.96300
PSA
37.30000
Logp
3.30050
IUPAC
6-bromonaphthalene-2-carboxylic acid
SMILES
C1=CC2=C(C=CC(=C2)Br)C=C1C(=O)O
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Pharmaceutical Intermediates
Chemical and Physical Properties
Melting Point
294-295°C
Density
1.648 g/cm3
Boiling Point
387.3ºC at 760 mmHg
Flash Point
188ºC
Appearance
White crystal powder or light brown solid
Export information
HS Code
29163990
Export Rebate
13%
UN No.
0.0
DG-Class
0.0
Risk Code
R36/37/38
Safety Label
Xn; Xi
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