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Jiangxi Tianxu Pharmaceutical Co., Ltd.
Jiangxi Tianxu Pharmaceutical Co., Ltd.
12 YRS
Jiangxi, China
Main Products:
2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride / Ethionamide / 2-Propylpyridine-4-Carbothioamide / 2,3-Dichloropyridine / D-P-Methyl Sulfone Phenyl Ethyl Serinate / 2-Aminobenzenethiol
Jiangxi, China
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Prothionamide / CAS 14222-60-7
OVERVIEW
Packaging
25 KG/Fibre Drum
Lead Time
14-30 days
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DESCRIPTION
Prothionamide
CAS：14222-60-7
Molecular formula: C9H12N2S
Molecular weight: 180.27
Structural type: 
Physicochemical properties: yellow solid powder
Storage conditions: Low temperature storage, storage temperature is 2 ~ 8 ° C.
Application: Isonicotinamide is a derivative of isonicotinic acid. Its mechanism of action is unknown and may inhibit the synthesis of peptides. The effect of this product on Mycobacterium tuberculosis depends on the drug concentration at the infection site. It only has bacteriostatic effect at low concentration and bactericidal effect at high concentration. This product has partial cross resistance with ethylthioisonicotinamide.
Typical Properties
Summary
As a derivative of isonicotinic acid, the mechanism of action of isonicotinic acid is unknown, which may inhibit peptide synthesis. The effect of this product on Mycobacterium tuberculosis depends on the drug concentration at the infected site. It only has antibacterial effect at low concentration, and bactericidal effect at high concentration. There is a partial cross resistance between this product and ethioisonicotinamide. Propisothamide is only effective against mycobacteria. This product is combined with other anti tuberculosis drugs in the treatment of tuberculosis by first-line drugs (such as streptomycin, isoniazid, rifampicin and ethambutol).
CAS No.
14222-60-7
Formula
C9H12N2S
Molecular Mass
180.27000
Exact Mass
180.07200
PSA
71.00000
Logp
2.36860
IUPAC
2-propylpyridine-4-carbothioamide
SMILES
CCCC1=NC=CC(=C1)C(=S)N
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Synthetic Anti Infective Drugs
Chemical and Physical Properties
Melting Point
140-143 °C
Density
1.136 g/cm3
Boiling Point
310.4 ºC
Flash Point
141.5 ºC
Appearance
white solid
Export information
HS Code
29333990
Export Rebate
13%
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