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JARI Pharmaceutical Co.,Ltd.
JARI Pharmaceutical Co.,Ltd.
20 YRS
Jiangsu, China
Main Products:
Gemcitabine Hydrochloride / Pemetrexed Disodium / Irinotecan Hydrochloride / Bicalutamide / Imatinib Mesylate / Fludarabine Phosphate / Torasemide
Jiangsu, China
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Pemetrexed Disodium / CAS 150399-23-8
OVERVIEW
Packaging
25 KG/Fibre Drum
Lead Time
14-30 days
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DESCRIPTION
Pemetrexed Disodium
Cas No：150399-23-8
Chinese name：培美曲塞二钠2.5水合物
Molecular formula：C20H19N5Na2O6
Molecular weight：471.37
Structural formula：
Quality standard：USP/EP
Typical Properties
Summary
Pemetrexed disodium is a tumor drug successfully developed by Eli Lilly Pemetrexed disodium is a multi-target antifolate preparation with pyrrolidine pyrimidine group in structure. It is a dual inhibitor of nucleotide synthase enzyme / dihydrofolate reductase. It can inhibit cell replication by destroying the normal folate dependent metabolism process in cells, and block three different enzyme targets that are crucial to the survival of cancer cells at the same time, So as to inhibit the growth of tumor.
CAS No.
150399-23-8
Formula
C20H19N5Na2O6
Molecular Mass
471.37400
Exact Mass
471.11300
PSA
196.92000
Logp
-1.03090
IUPAC
disodium;(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate
SMILES
C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
Attribute classification
Category
API & Intermediate > Antineoplastic Agents
Chemical and Physical Properties
Melting Point
36-38°C
Boiling Point
160 ℃
Flash Point
160°C/20mm
Appearance
Crystalline solid
Export information
HS Code
2933990090
Export Rebate
9%
UN No.
0.0
DG-Class
0.0
Risk Code
R36/38；R60；R61；R68
Safety Label
T
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