Acetazolamide

Product introduction:

Acetazolamide is the prototype of carbonic anhydrase inhibitor. Compared with acetazolamide, acetazolamide has one more methyl in nitrogen atom, and they are all derivatives of sulfonamide. This structure reduces the ionization effect of acetazolamide, so the intraocular permeability is enhanced compared with acetazolamide. White acicular crystal or crystalline powder. Melting point 256-261 ℃ (decomposition). Odorless, slightly bitter. Slightly soluble in boiling water, slightly soluble in water, ethanol, almost insoluble in chloroform or ether, easily soluble in ammonia solution.

CAS：59-66-5

Molecular formula: C₄H₆N₄O₃S₂

Molecular weight: 222.25

Structural type:

Product purpose:

This product is a diuretic. It is a carbonic anhydrase inhibitor. After taking it, it inhibits carbonic anhydrase in renal tubular epithelial cells, reduces the formation of H₂CO₃ and the production of H +. Therefore, the exchange of H ⁺ and Na⁺ slowed down greatly. As a result, the excretion of HCO₃^-，Na⁺，K⁺ increased and the urine volume increased. The product can also inhibit the secretion of aqueous humor and reduce intraocular pressure. It is used to treat glaucoma, mild cardiac edema, etc.