Nifedipine / CAS 21829-25-4

Nifedipine is a dihydropyridine calcium antagonist, which can inhibit the Ca2 + uptake of myocardium and vascular smooth muscle, dilate coronary artery, increase coronary blood flow, improve myocardial tolerance to ischemia, dilate peripheral small arteries, reduce peripheral vascular resistance, relieve coronary artery spasm, increase coronary blood flow, improve myocardial hypoxia, and reduce blood pressure. Low dose coronary artery dilation does not affect blood pressure, so it is a good anti angina drug. For the prevention and treatment of angina pectoris of coronary heart disease, it has no adverse effect on respiratory function, especially for angina pectoris caused by coronary artery spasm and angina pectoris with respiratory obstructive disease, the effect is the best, and its curative effect is better than that of traditional Chinese medicine β Receptor blockers. It is also suitable for various types of hypertension, including severe and refractory hypertension. It can be used for a long time in the treatment of refractory congestive heart failure. It is also used in the treatment of primary pulmonary hypertension, diffuse esophageal spasm, bronchial asthma, duodenal ulcer, urethral obstruction, exercise-induced asthma, achalasia, etc.