Rifampicin
Synonymous:3-(((4-Methyl-1-piperazinyl)imino)-methyl)rifamycin; Abrifam; Dipicin; Eremfat; R/AMP; RIF; Rifa;Rifadin I.V.;(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
Related parameters
CAS:13292-46-1
EINECS:236-312-0
Molecular formula: C43H58N4O12
Molecular weight: 822.9402
Security information
Risk term: R22
Irritant: irritating to eyes, respiratory system and skin.
Safety terminology: S26
If you come into contact with your eyes accidentally, please immediately rinse with plenty of water and seek the advice of a doctor. Wear appropriate protective clothing.
Physicochemical properties
Melting point: 183 ° C (Dec.)
Melting point: 183 ℃ (Dec.)
Relative density: 1.34g/cm3
purpose
It has broad-spectrum antibacterial effect and has good antibacterial activity against gram-positive cocci and Mycobacterium tuberculosis. The antibacterial spectrum is the same as rifampicin.
Rifampicin is a broad-spectrum antibiotic belonging to rifamycin family. It has strong antibacterial effect on Mycobacterium tuberculosis, and also has curative effect on Gram-positive or negative bacteria and viruses. Red or dark red crystalline powder, insoluble in water. Generally, it is a capsule or tablet oral drug, which has a synergistic effect with other anti tuberculosis drugs and delays the generation of drug-resistant strains.
IUPAC
[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate
SMILES
C[C@H]1/C=C/C=C(\C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C=N/N5CCN(CC5)C)/C