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Changzhou Golden Bright Pharmaceutical Factory
Changzhou Golden Bright Pharmaceutical Factory
24 YRS
Jiangsu, China
Main Products:
N5-Ethyl-L-Glutamine / Piroxicam / Minoxidil / Leflunomide
Jiangsu, China
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Leflunomide / CAS 75706-12-6
OVERVIEW
Packaging
25 KG/Fibre Drum
Lead Time
In Stock
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DESCRIPTION
Typical Properties
Summary
Leflunomide is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide. It has a role as a non-steroidal anti-inflammatory drug, an antineoplastic agent, an antiparasitic agent, an EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor, a hepatotoxic agent, a prodrug, a pyrimidine synthesis inhibitor, an immunosuppressive agent, an EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor and a tyrosine kinase inhibitor. It is a monocarboxylic acid amide, a member of isoxazoles and a member of (trifluoromethyl)benzenes.
CAS No.
75706-12-6
Formula
C12H9F3N2O2
Molecular Mass
270.20700
Exact Mass
270.06200
PSA
55.13000
Logp
3.32710
IUPAC
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
SMILES
CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Antipyretic Analgesics
Chemical and Physical Properties
Melting Point
163-168°C
Density
1.392 g/cm3
Boiling Point
289.3ºC
Flash Point
128.8ºC
Appearance
Grayish white crystalline solid
Export information
HS Code
29349990
Export Rebate
10%
UN No.
2811
DG-Class
6.1
Risk Code
R22; R36/37/38
Safety Label
Xn,Xi
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