L-Pyroglutamic acid
Product introduction:
L-pyroglutamic acid is also known as L-pyroglutamic acid and l-pyrolysine. The scientific name is l-2-pyrrolidone-5-carboxylic acid. The precipitates from the mixture of ethanol and petroleum ether are colorless orthorhombic biconical crystals with a melting point of 162 ~ 163 ℃. Soluble in water, alcohol, acetone and glacial acetic acid, slightly soluble in ethyl acetate, insoluble in ether. Specific rotation: - 11.9 ° (C = 2, H2O). It is prepared from 42% glutamic acid aqueous solution by heating, dehydration, concentration, crystallization, washing and drying.
Chemical property:
Appearance：Colorless crystal
Melting point ：162-163 ℃
Solubility： soluble in water, alcohol, acetone and glacial acetic acid, slightly soluble in ethyl acetate, insoluble in ether.
Production method:
There are semi synthetic method, enzyme conversion method and total synthetic method. At present, the main method of industrial production is the semi synthesis method with glutamic acid as raw material. The 42% glutamic acid aqueous solution was heated at 140 ℃ for 3h to obtain the reaction solution with L-pyroglutamic acid as the main component. After concentration under reduced pressure, crystallization, washing and drying, L-pyroglutamic acid was obtained with a conversion of 94%.
Purpose:
Human skin contains a water-soluble substance with moisturizing function - natural moisturizing factor, which is roughly composed of amino acids (40%), pyroglutamic acid (12%), inorganic salts (18.5% of Na, K, CA, Mg, etc.) and other organic substances (29.5%). Therefore, pyroglutamic acid is one of the main components of skin natural moisturizing factor, and its moisturizing ability is much higher than glycerol and propylene glycol. It is non-toxic and non irritating. It is an excellent raw material for modern skin care and hair care cosmetics. Pyroglutamic acid also inhibits the activity of tyrosine oxidase, so as to prevent the deposition of "melanoid" substances in the skin and whiten the skin. It can soften cutin and can be used in nail cosmetics. In addition to its application in cosmetics, L-pyroglutamic acid can also form derivatives with other organic compounds. It has special effects in surface activity, transparency and brightness. It can also be used as surfactant for detergent; Chemical reagent for the resolution of racemic amine; Organic intermediates.
In human skin, there is a kind of water-soluble substance with moisturizing function natural moisturizing factor, which is composed of amino acids (40%), pyroglutamic acid (12%), inorganic salts (18.5% of Na, K, CA, Mg, etc.) and other organic substances (29.5%). Therefore, pyroglutamic acid is one of the main components of skin natural moisturizing factor, and its moisturizing ability is far more than glycerol and propylene glycol. It is a good raw material for modern skin care and hair care cosmetics. Pyroglutamic acid can also inhibit the activity of tyrosine oxidase, thus preventing the deposition of "melanoid" substances in the skin and whitening the skin. It has softening effect on cutin and can be used in nail cosmetics. In addition to its application in cosmetics, L-pyroglutamic acid can also form derivatives with other organic compounds, which have special effects in surface activity, transparency and brightness. It can also be used as surfactant and detergent; Chemical reagent for resolution of racemic amine; Organic intermediates.
IUPAC
(2S)-5-oxopyrrolidine-2-carboxylic acid
Sichuan, China
