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Ningbo Menovo Pharmaceutical Co., Ltd.
Ningbo Menovo Pharmaceutical Co., Ltd.
20 YRS
Anhui, China
Main Products:
Losartan Potassium / Ivabradine HCl / Perindopril Erbumine / Rosuvastatin Calcium / Atorvastatin Calcium / Valsartan / Perindopril Arginine
Anhui, China
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Perindopril Erbumine / CAS 107133-36-8
OVERVIEW
Packaging
25 KG/Fibre Drum
Lead Time
14-30 days
Max Capacity
10 MT/Year
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DESCRIPTION
Perindopril Erbumine
Chinese Name: 培哚普利叔丁胺盐
CAS No.: 107133-36-8
Molecular formula:C23H43N3O5
Molecular weight: 441.60
Structural type:
Appearance: White or whitish crystalline powder
Application: Hypotensor
Typical Properties
Summary
Perindopril is an inhibitor of an enzyme (angiotensin converting enzyme) that converts angiotensin I to angiotensin II. This kind of invertase or kinase is a kind of peptidolytic enzyme. It can convert angiotensin I into angiotensin II, which is used to constrict blood vessels. It can also degrade bradykinin, which is used to dilate blood vessels, into inactive heptapeptide. Inhibition of angiotensin converting enzyme results in a decrease of angiotensin II in plasma, which leads to an increase in plasma renin activity (by inhibiting the negative feedback of renin release) and a decrease in aldosterone secretion. Because angiotensin-converting enzyme inactivates bradykinin, inhibition of angiotensin-converting enzyme can also increase the activity of circulating and local kallikrein kinin system (and thus prostaglandin system). This mechanism may be related to the effect of angiotensin converting enzyme inhibitors on lowering blood pressure, and may also be related to some side effects (such as cough). Perindopril acts through its active metabolite perindoprila.
CAS No.
107133-36-8
Formula
C23H43N3O5
Molecular Mass
441.60500
Exact Mass
441.32000
PSA
121.96000
Logp
3.71330
IUPAC
(2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid;2-methylpropan-2-amine
SMILES
CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O.CC(C)(C)N
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Pharmaceutical Raw Materials
Chemical and Physical Properties
Melting Point
126-128 ºC
Density
1.15 g/cm3
Boiling Point
537.4 ºC
Flash Point
278.8 ºC
Appearance
white solid
Acidity and Basicity
alkalinity acidness
Export information
HS Code
29339900
Export Rebate
13%
Risk Code
R36/37/38
Safety Label
Xi
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