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Sichuan Xieli Pharmaceutical Co., Ltd.
Sichuan Xieli Pharmaceutical Co., Ltd.
32 YRS
Sichuan, China
Main Products:
Rutin / Troxerutin / Hesperidin / Diosmin / Ursodeoxycholic Acid / Artemisinin / Berberine HCL / Rotundine / Indigo / Cytisine
Sichuan, China
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Rotundine / CAS 10097-84-4
OVERVIEW
Packaging
25 KG/Fibre Drum
Lead Time
14-30 days
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DESCRIPTION
Rotundine
【Molecular composition】：
【CAS】：10097-84-4
【source】：Rotundine
【Certification】：—
【Spec】：CP
【DMF】：—
【use】：
It can be used for the clinical treatment of stomachache, dysmenorrhea, uterine spasm after childbirth, headache, insomnia and other diseases.
Typical Properties
Summary
Rotundine, also known as Rotundine and l-tetrahydropalmatine, with chemical name of 2,3,9,10-tetramethoxy-5,8,13,13a-tetrahydro-6h-dibenzo [a, g] quinazine, is a levorotatory substance of tetrahydropalmatine (DL THP). It is a blocker of dopamine receptor in the brain and preferentially blocks brain areas rich in dopamine receptors, such as cortex and striatum, It can achieve analgesic effect by strengthening the function of internal anti pain system and inhibiting the pivot in the transmission of pain information. Its analgesic effect is weaker than pethidine and stronger than general analgesics. It has no respiratory inhibitory effect under the therapeutic dose and does not cause gastrointestinal smooth muscle spasm. It has a certain effect on acute and chronic persistent pain and visceral dull pain. It was first listed in China in 1985. It is suitable for patients with insomnia due to pain. It can also be used for pain of gastric ulcer and duodenal ulcer, menstrual pain, uterine contraction pain after delivery, tension insomnia, spastic cough, etc.
CAS No.
10097-84-4
Formula
C21H25NO4
Molecular Mass
355.42800
Exact Mass
355.17800
PSA
40.16000
Logp
3.31440
IUPAC
2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline
SMILES
COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Antipyretic Analgesics
Chemical and Physical Properties
Density
1.23 g/cm3
Boiling Point
482.9ºC at 760 mmHg
Flash Point
138.7ºC
Appearance
It is white or yellowish flake or columnar crystal, odorless, slightly bitter, and turns yellow when exposed to light and heat. Insoluble in water, slightly soluble in ethanol, easily soluble in chloroform and ether. Its solubility in sulfuric acid brine is large, and it is mostly made into injections.
Export information
HS Code
29339900
Export Rebate
13%
UN No.
0.0
DG-Class
0.0
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