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Zhongshan Enantiotech Corporation Limited
Zhongshan Enantiotech Corporation Limited
17 YRS
Guangdong, China
Main Products:
Methyl 2-(2-Chloro-1-Iminoethyl)Hydrazinecarboxylate / Aprepitant / Apremilast / Solifenacin / 5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-c]Pyridine-2-Carboxylic acid Hydrochloride / Avibactam Sodium / Vonoprazan Fumarate / Nintedanib
Guangdong, China
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Nintedanib / CAS 656247-17-5
OVERVIEW
Packaging
25 KG/Fibre Drum
Lead Time
14-30 days
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DESCRIPTION
Product Name:Nintedanib
CAS:656247-17-5
Purity：98.0%
Inside Code：NDN05
Structural type:
It is mainly used for tumor treatment, such as colorectal cancer, ovarian cancer, multiple myeloma, etc.
Typical Properties
Summary
Nintedanib is a member of the class of oxindoles that is a kinase inhibitor used (in the form of its ethylsulfonate salt) for the treatment of idiopathic pulmonary fibrosis and cancer. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor, a vascular endothelial growth factor receptor antagonist, a fibroblast growth factor receptor antagonist and an angiogenesis inhibitor. It is an aromatic ester, a methyl ester, a member of oxindoles, an enamine, an aromatic amine, an aromatic amide and a N-alkylpiperazine. It is a conjugate base of a nintedanib(1+).
CAS No.
656247-17-5
Formula
C31H33N5O4
Molecular Mass
539.62500
Exact Mass
539.25300
PSA
94.22000
Logp
3.70270
IUPAC
methyl 2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate
SMILES
CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Pharmaceutical Raw Materials
API & Intermediate > Pharmaceutical Intermediates
API & Intermediate > Pharmaceutical Intermediates
Chemical and Physical Properties
Density
1.284±0.06 g/cm3
Boiling Point
742.2±60.0 °C
Appearance
Yellow solid.
Acidity and Basicity
neutral reducibility
Export information
HS Code
29335990
Export Rebate
13%
UN No.
0.0
DG-Class
0.0
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