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Urapidil Hydrochloride

CAS NO.： 64887-14-5

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Specification： 98.0-102%

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Lead Time： 14-30 days

Max Capacity： -

Packing： 25KG/Fibre Drum

Product Detail

Properties

Urapidil hydrochloride

English Name: urapidil hydrochloride

CAS No.: 64887-14-5

Molecular formula: C20H30ClN5O3

Molecular weight: 423.94

EINECS No.: 636-348-0

Application:

Urapidil hydrochloride is a selective drug α The antihypertensive effect of receptor blockers has both central and peripheral mechanisms, but mainly peripheral dual mechanisms. In the periphery, it blocks postsynaptic α 1 receptor, inhibit the vasoconstriction of catecholamine, so as to reduce peripheral vascular resistance and cardiac load; In the central nervous system, the activity of the circulatory center is regulated by stimulating serotonin-1A receptor to prevent the increase of blood pressure and heart rate caused by sympathetic reflex. The dual mechanism can reduce blood pressure rapidly, and the dual channel metabolism is safe to use.

Purpose:

It is used to treat various types of hypertension and hypertension

Properties

Urapidil is a sympatholytic antihypertensive drug. It acts as an α1-adrenoceptor antagonist and as an 5-HT1A receptor agonist Although an initial report suggested that urapidil was also an α2-adrenoceptor agonist, this was not substantiated in later studies that demonstrated it was devoid of agonist actions in the dog saphenous vein and the guinea-pig ileum. Unlike some other α1-adrenoceptor antagonists, urapidil does not elicit reflex tachycardia, and this may be related to its weak β1-adrenoceptor antagonist activity, as well as its effect on cardiac vagal drive. Urapidil is currently not approved by the U.S. Food and Drug Administration, but it is available in Europe.

CAS No.

64887-14-5

Formula

C20H30ClN5O3

Molecular Mass

423.93700

Exact Mass

423.20400

PSA

71.74000

Logp

1.59470

IUPAC

6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione;hydrochloride

Matter Classification

organic

Category

Melting Point

156-158ºC

Boiling Point

549ºC at 760 mmHg

Flash Point

285.8ºC

Appearance

White or off white crystalline powder

HS Code

29420000

UN No.

0.0

DG-Class

0.0

Risk Code

22-36/37/38

Safety Label

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Urapidil hydrochloride