N-acetylneuraminic acid is the most widely distributed in nature, mainly composed of glycoprotein, glycolipid or bacterial capsule substance in animal cell membrane or secretion liquid. Sialic acid is a carbohydrate widely existing in nature, and also a basic component of many glycoproteins, glycopeptides and glycolipids. It has a wide range of biological functions, such as the regulation of half-life of blood protein, neutralization of various toxins, cell adhesion, immune antigen antibody reaction and protection of cell dissolution. The biochemical derivatives of sialic acid are also commonly used in the synthesis of drugs.