Neomycin Sulphate
Product Category:BAPI for veterinary use
Cas.NO:1405-10-3
Quality standard:CvP, EP, USP
Approval number of veterinary drug products:ShouYaoYuanZi120541519
Specification:active pharmaceutical ingredients
Molecular formula:C37H53NO8
Molecular weight:639.82
To use:aminoglycoside antibiotics. Used for colibacillosis caused by gram-negative bacteria such as avian colibacillosis and salmonella, pullorum of chicken etc.
Pharmacodynamics Neomycin belongs to aminoglycoside antimicrobial drug, antibacterial spectrum and kanamycin are similar. It has a strong antibacterial effect on most gram-negative bacilli, such as escherichia coli, proteus, salmonella and pasteurella multocides, and is also sensitive to staphylococcus aureus.
Storage:seal and store in a dry place.
Neomycin Sulfate is the sulfate salt form of neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, neomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.
IUPAC
(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid
Matter Classification
organic
Melting Point
>187°C (dec.)
Boiling Point
1046.1ºC at 760 mmHg
Appearance
White or off white powder
Acidity and Basicity
acidness
CRO
