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Synonymous | Tocofersolan；TPGS |
Structure |
|
CAS | 9002-96-4 |
Molecular Formula | C35H58O6 |
Molecular Weight | 574.831 |
Appearance | off white or yellowish waxy solid |
Packing | 25kg；1kg；5kg |
Uses | TPGS a water-soluble derivative of vitamin E from natural sources, is a white or light yellow waxy solid, almost tasteless, soluble in water and most polar organic solvents such as ethanol. It is amphiphilic and miscible with water to form a variety of liquid crystal phases. The excipient has a melting point of 37-41 ℃ and is thermally stable at a temperature ≤ 200 ℃. |
Storage | 2-8°C |
Vitamin E polyethylene glycol succinate (tpgs) is a water-soluble derivative of vitamin E, which is formed by the reaction of the carboxyl group of vitamin E succinate with the hydroxyl group of polyethylene glycol. Because it contains both vitamin E ester affinity group and polyethylene glycol hydrophilic long chain, it has good surfactant properties and water solubility, can significantly increase the absorption of insoluble drugs in the gastrointestinal tract and improve the bioavailability.
Because vitamin E polyethylene glycol succinate contains both vitamin E ester affinity group and polyethylene glycol hydrophilic long chain, it has good surfactant properties and water solubility, can significantly increase the absorption of insoluble drugs in the gastrointestinal tract and improve the bioavailability.
In recent years, many studies have found that tpgs not only can be used as pharmaceutical excipients, but also has many unique characteristics, such as absorption enhancer and reversal agent of multidrug resistance. Tpgs can also be used in precursor drugs, micelles, liposomes and tpgs copolymer carriers to improve the solubility, permeability and stability of the preparation, so as to achieve slow, controlled-release and targeted effects and promote the absorption of drugs.
Vitamin E polyethylene glycol succinate has been widely used in the research of preparations as solubilizer, absorption promoter, emulsifier, plasticizer and carrier of water-insoluble or fat soluble drug delivery system, such as solid dispersion, carrier for ocular administration, carrier for intranasal administration, etc. In foreign countries, vitamin E polyethylene glycol succinate has been widely used in the research of preparations as solubilizer, absorption promoter, emulsifier, plasticizer and carrier of water-insoluble or fat soluble drug delivery system, such as solid dispersion, carrier for ocular administration, carrier for intranasal administration, etc. In recent years, many studies have found that tpgs not only can be used as pharmaceutical excipients, but also has many unique characteristics, such as absorption enhancer and reversal agent of multidrug resistance. Tpgs can also be used in precursor drugs, micelles, liposomes and tpgs copolymer carriers to improve the solubility, permeability and stability of the preparation, so as to achieve slow, controlled-release and targeted effects and promote the absorption of drugs.
Manufacturing
