b
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Structure：
4-chloro-6-ethyl-5-fluoropyrimidine (IV) is the key intermediate for the synthesis of voriconazole (V), and ethyl fluoropropionyl acetate is required for the synthesis of 4-chloro-6-ethyl-5-fluoropyrimidine (IV). Voriconazole is a new broad-spectrum triazole antifungal drug, which inhibits 14 mediated by cytochrome P450 in fungi α- Sterol demethylation, thereby inhibiting ergosterol biosynthesis.
Manufacturing
