Potassium Sodium Dehydroandroandrographolide Succinate

Synonymous：14-Dehydroxyl- 11,12-Dehydroandrographolide -3,19- Succinate Potassium Sodium Monohydrate

Structure：

Molecular Formula：C₂₈H₃₄KNaO₁₀·nH₂O

Molecular Weight： n=0 592.66 n=1 610.68

CAS Number：6700-42-5

NMPA approval No.：H20057578

National Drug Standards：YBH25612005 Draft Quality Standards for Comments(2016)

Test	CP	Results
Color & Appearance	White to yellowish powder Orcrystalline powder	White powder
Assay ( HPLC )(calculated by anhydrous substance)	98%～102%	99.1%
Impurities (total) Unkown Impurities(individual)	NMT 2.0 % NMT1.0%	0.3% 0.08%
pH	6.0～7.5	6.6
Loss on Drying	NMT 4.0 %	0.9%
Heavy metals (as Pb) Residual Solvents(acetone ) Bacterial endotoxin	NMT 10 ppm NMT 0.5% LT 0.25EU/mg	Conforms Conforms Conforms

Package: 1kg

Storage ：Preserve in tight, containers ,store at temperature blow 20℃.

Properties

PotassiuM sodiuM Dehydroandrographolide Succinate is a new derivative of andrographolide, which is prepared by esterification of andrographolide and succinic anhydride, and then salt formation. A new antiviral drug, a traditional Chinese medicine product synthesized from andrographolide and succinic anhydride, has obvious anti-inflammatory, antipyretic and anti-cancer effects. It is clinically used for viral pneumonia, upper respiratory tract infection, infant pneumonia, acute and chronic bronchitis, gastrointestinal infection, biliary infection, urinary tract infection, herpes simplex, etc.

CAS No.

6700-42-5

Formula

C28H34KNaO10

Molecular Mass

592.65200

Exact Mass

592.16900

PSA

159.16000

Logp

1.27740

IUPAC

potassium;sodium;4-[[(1R,2R,4aS,5R,8aS)-2-(3-carboxylatopropanoyloxy)-1,4a-dimethyl-6-methylidene-5-[(2E)-2-(2-oxofuran-3-ylidene)ethyl]-3,4,5,7,8,8a-hexahydro-2H-naphthalen-1-yl]methoxy]-4-oxobutanoate

Matter Classification

organic

Category

Appearance

Yellowish solid powder

HS Code

3004905990

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Hunan Zhongqi Pharmaceutical Co., Ltd.