It is an in vivo and in vitro insecticide mainly for adult fleas, filariasis and scabies of pet cats and dogs
Properties
Summary
Selamectin is a kind of insecticide in vivo and in vitro mainly for adult fleas, filariasis and scabies of pet dogs and cats. The mechanism of action of celamycin is the same as that of other avermectins γ- Aminobutyric acid (GABA) agonists induce the release of presynaptic GABA, and then increase the permeability of membrane to Cl ¯. On the other hand, the drug can open the chloride channel controlled by glutamate, increase the permeability of Cl ¯, and lead to membrane potential hyperpolarization, thus blocking the transmission of nerve signal, causing rapid, lethal and non spastic neuromuscular paralysis and death.