Dienogestrel

Product introduction:

Dinogestrin is a newly listed selective luteal hormone drug in recent years. It can play a role in stabilizing endometrial tissue by specifically binding ethylene nortestosterone and progesterone derivatives. Studies have found that tumor necrosis factor (TNF). And interleukin-8 (IL-8) increased in patients with endometriosis.

CAS：65928-58-7

Molecular formula: :C₂₀H₂₅NO₂

Molecular weight: 311.43

Structural type:

Product purpose:

Dienogestrel is a mixed progesterone with dual properties of 19 nortestosterone derivative and progesterone derivative; Therefore, it has both the pharmacological advantages of natural and synthetic progesterone, and has high progesterone activity. A large-scale randomized, double-blind, placebo-controlled clinical trial conducted by Harada et al. Showed that after taking dinogestrin 2mg / D for 24 weeks, the efficacy of dinogestrin in improving endometriosis related lower abdominal pain, low back pain and sexual intercourse pain was equivalent to that of buserelin, but the rate of adverse reactions such as vaginal bleeding and decreased bone mineral density was significantly reduced, and the tolerance was better.