2,3,4,6-tetrakis-O-trimethylsilyl-D-glucono-1,5-lactone are antidiabetic agents and intermediates of Da Glenn Jing. 2,3,4,6-tetrakis-O-trimethylsilyl-D-glucono-1,5-lactone was used as a reagent for the synthesis of C-glucose containing trans cyclohexane and as a sodium glucose cotransporter 2 inhibitor.