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1. The company has strong R&D strength (the research background of Angel Yeast and East China Medicine), and the quality standard conforms to USP.
2. The production capacity is stable, with an annual capacity of 500T.
3. Flexible production, providing OEM and non-standard customized services.
4. Operating of ISO9001, ISO22000, ISO14001, OHSAS18001 , HACCP, and other management systems.
BRC Global Food Safety, Ethical Audit, Kosher, Halal Certification, etc.
Highlights of Vitamin K2(MK-7):
1. All-trans MK7 (high bioavailability)
2. Kids II Fareast Vitamin K2 is a crystal with a purity of more than 99.9%, which is almost free of impurities and has high stability
3. The MCT double-embedded powder with water dispersion can expand its application scope, such as solid drinks
4. The content and auxiliary materials can be customized according to the formula requirements of different customers
5. High stability: the stability test data of 12 months showed that the degradation rate was only 1.4% (30~40% compared with the degradation rate of peers)
Product Name: | Vitamin K2 | CAS No.: | 2124-57-4 |
MF: | C46H64O2 | Abbr: | MK-7 |
Other Names: | Menaquinone-7; Menaquinone K7; Trans-Menaquinone 7; Vitamin MK 7; Vitamin K2(35) | Type: | Food; Health Care Products; Medicine; Vitamins; |
Grade Standard: | Food Grade | Assay VK2-7: | Powder: ≥2000ppm, ≥10000ppm; Oil: ≥1500ppm, ≥4500ppm |
Transport Package: | Al foil bag/Box | Shelf Life: | 24 Months |
Appearance: | Yellow Powder or Oil | Origin: | China |
Application: | Vitamin K2 (MK-7) can increase bone density and promote cardiovascular health. | ||
500 Metric Tons Per Year
Packaging Details: | 10 KG/Box, with the inner aluminum foil bag or according to customer requirements |
Port: | Shanghai Port, or other main ports in China |
Item | Specification | Result |
Colour | White to light yellow | Conforms |
Smell | Unique smell and taste, without peculiar smell | Conforms |
State | Powder | Conforms |
Impurities | No visible impurities | Conforms |
VK2 Assay | ≥ 2000 ug/g | 2018.6 ug/g |
Moisture | ≤ 5.0% | 3.44% |
Sulfated ash | ≤ 3.0% | 0 |
Total bacterial count | ≤1000 CFU/g | <100 CFU/g |
Mold & Yeast | ≤100 CFU/g | <10 CFU/g |
Coliform bacteria | <3.0 MPN/g | < 0.3 MPN/g |
Escherichia coli | <3.0 MPN/g | < 0.3 MPN/g |
Salmonella /25g | Absent | ND |
Staphylococcus aureus | Absent | ND |
Arsenic | < 0.1 mg/kg | < 0.01mg/kg |
Lead | <0.1 mg/kg | <0.02 mg/kg |
Mercury | ≤ 0.05 mg/kg | <0.003mg/kg |
Cadmium | < 0.1mg/kg | 0.0037 mg/kg |
Inner: Aluminum Foil bag, Outer: Carton or cardboard drum.
Inner bag aluminum foil packaging, outer carton or cardboard drum, various specifications.
Shelf life: Store in a cool, dry, and airy place, protect from light, with a shelf life of 24 months.
Hubei Magic Health Technology Co., Ltd is established in 2021, jointly funded by Hangzhou Zhongmei Huadong Medicine Co., Ltd, Zhejiang Huida Biotech Co., Ltd, and Angel Yeast Co., Ltd.
● Specializing in the R&D and manufacturing of nutraceutical food raw materials and personal care functional raw materials based on microbial technology.
● Located in Biological Industrial Park, Xiaoting District, Yichang City, Hubei, China. Total covered area: 148,000㎡, total construction area: 164,000㎡ , total planned investment: 1.16 billion RMB(for three phases.
● It has given full play to the sources and advantages of the three shareholders in product R&D, technological innovation, manufacturing, quality certification and other aspects, and is committed to being an "industrialized, large-scale and international" technical innovation company with the comprehensive health industry being the backbone force.
Research direction:
1. Major health areas: vitamin K2, PQQ, hyaluronic acid, etc;
2. Protection areas: Icodoin, hyaluronic acid, ergothioneine, etc;
3. Technical cooperation.
Vitamin K, also known as coagulation vitamin, belongs to a kind of vitamin and has the biological activity of phylloquinone. It was first discovered and extracted from animal liver and sesame oil by Danish chemist Dam in 1929. It was named "vitamin K" in 1934, which comes from the German word "Koagulation”. In 1939, Doyce from the United States extracted vitamin K and determined its chemical formula and structure. In 1943, they won the Nobel Prize in physiology and medicine.
Vitamin K includes K1, K2, K3, K4 and other forms, among which K1 and K2 exist naturally and belong to fat soluble vitamins, K3 and K4 are synthetic and water-soluble vitamins.
The chemical properties of the four kinds of vitamin K are relatively stable and acid and heat resistant. There is little loss in normal cooking, but they are sensitive to light and are easy to be decomposed by alkali and ultraviolet light.
Vitamin K2 (MK-7) is a type of vitamin K2, that is, seven isoprene units on the side chain of vitamin K2. It is a fat-soluble vitamin and one of the indispensable vitamins in the human body. It is also known as MK-7, menadione-7 and vitamin K2(35).
●Coagulation activity
Vitamin K is an essential substance for the synthesis of four coagulation proteins (Prothrombin, Transformation accelerating factor, Anti hemophilia factor and Situ factor) in the liver, it plays an auxiliary role in the synthesis of γ- carboxyl glutamic acid.
If vitamin K is deficient, the above four coagulation factors synthesized by the liver are abnormal protein molecules, and the ability to catalyze coagulation will be greatly reduced.
Vitamin K2 has the same coagulation function and physiological function as vitamin K1. It can promote the liver to synthesize prothrombin (i.e., coagulation factor II) and regulate the synthesis of other three coagulation factors (factors VII, IX and X). Its coagulation mechanism acts as the coenzyme of Glutamic acid- γ- Carboxylase, which carboxylates the glutamic acid residue in prothrombin into γ- Carboxylated glutamic acid residues (Gamma-carboxyglutamate, abbreviated as GLA), thus, it has the ability to bind with Ca2+, connect the phospholipid surface and regulatory protein, and has coagulation activity. If Vitamin K is deficient, the synthesis of factors II, VII, IX and X will stay in the precursor state, and the prothrombin time is prolonged, which is easy to cause bleeding.
The National Health and Family Planning Commission of China has approved the fortification of vitamin K2 in milk powder prepared for children and pregnant women, which can avoid bleeding symptoms caused by incomplete development of the coagulation system or vitamin K deficiency caused by a dietary deficiency in children and newborns.
●Effects on Bone Health
The effect of vitamin K2 on bone health has attracted more and more attention of scientists. A large number of clinical trials have proved that vitamin K2 supplementation has a positive effect on bone health.
Bone Gla protein（abbreviated as BGP）, Osteocalcin (abbreviated as OC), Matrix Gla Protein(abbreviated as MGP) and Protein S are the main Gla-containing proteins in calcified tissues.
Vitamin K2, as a coenzyme of Glutamic acid- γ- Carboxylase, can carboxylate the glutamate residue on osteocalcin into Gla. After carboxylation, osteocalcin is activated. Gla binds and deposits with hydroxyapatite calcium to promote bone mineralization. If lacking vitamin K2 in the body, it will lead to incomplete carboxylation of osteocalcin and the formation of undercarboxylated Osteocalcin (ucOC). The glutamic acid residues with incomplete carboxylation will affect the mineralization of bone.
In recent years, the relationship between the carboxylation degree of osteocalcin and bone health has attracted extensive attention in the study of biochemical indexes of bone metabolism. UcOC content is directly proportional to osteoporosis and fracture probability, so ucOC can predict the occurrence of hip fracture. Serum ucOC increases with age, especially in early postmenopausal women. Vitamin K2 supplementation can reduce serum ucOC and fracture.
●Prevention of Vascular Sclerosis
Matrix Gla protein (MGP) is a vitamin K-dependent Gla protein synthesized in cartilage and vascular wall cells. This protein is an important inhibitor of arterial calcification, and its activity depends on the γ- Glutamic acid carboxylation of vitamin K. The deficiency of vitamin K2 can lead to incomplete carboxylation of MGP (ucMGP), which leads to the loss of biological function of the protein. Non-carboxylated MGP cannot effectively transport calcium ions in the blood, resulting in the increase of blood calcium concentration, resulting in the calcification of blood vessels.
●Tumor Inhibition
Studies have shown that vitamin K2 has a positive effect on the inhibition of liver cancer. In multiple liver-cancer studies, vitamin K2 can reduce the recurrence rate of liver cancer and improve the survival rate of patients. The study also found that myeloma cells, leukemia cells, and gastric adenocarcinoma cells are sensitive to vitamin K2. Vitamin K2 can effectively inhibit the growth of tumor cells, and inducing apoptosis is one of its important mechanisms. So far, no tumor inhibition effect of vitamin K1 has been reported.
●New Discoveries in Alzheimer's Disease
Throuah the fruit fly experiment, researchers in the Northern Illinois Universitv of the United States found that vitamin K2 can improve the electron transport in mitochondria, so it can restore the damaged mitochondria in cells to normal, and then promote energy production. This is expected to solve the interference of cell mitochondria and electron transmission in patients with Alzheimer's disease and relieve the disease. There was no such finding for Vitamin K1.
●Application of Relieving Peripheral Nerves
As acoenzvme, vitamin K can participate in the electron transport and redox process in cells and tissues, and has a gentle and relaxing effect on peripheral nerves and muscle tissues.
Table 3. Recommended limits and levels of vitamin K2 in the European Union
The daily adequate intake (AI) of vitamin K in the Dietary Guidelines for Chinese Residents 2016 is shown in Table 4 below:
Angel yeast Co., Ltd. was founded in 1986, specializing in the processing and manufacturing of yeast and yeast derivatives. Its production and marketing scale ranks first in Asia and third in the world. It has established a global marketing network, regional headquarters and application technology service centers in Beijing, Shanghai, Chengdu, Shenyang, Wuhan, Guangzhou, Cairo and other cities, and products are exported to more than 150 countries and regions.
Angel yeast Co., Ltd. has passed ISO9001 quality management system certification, HACCP certification, GMP certification and kosher certification, and the testing center has been recognized by CNAs, providing a reliable guarantee for the production of products.
Maiggic® vitamin K2 (MK-7) is produced by Angel yeast Co., Ltd., entrusted by Hubei Magic Health Technology Co., Ltd. Hubei Magic Health Technology Co., Ltd has a series of internationally leading production and application technologies.
Natural Vitamin K2 Mk7 in Powder/Oil; Vitamin K2 (35) Food Additive; High Quality Vitamin K2 (35) /Menlaquinone 7/Vitamin Mk 7 CAS 2124-57-4; Active Pharmaceutical Ingredients Vitamin K2; Vitamin K2 Powder Pure Vitamin Raw Material
We are a manufacturer that owns factories both in Hubei Province. They cover an area of about 323 mu. You are warmly welcome to visit us!
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