Trifluoroacetic anhydride (tfaa) is a strong dehydrating agent with a wide range of chemical reactivity. It is used as a solvent, catalyst, dehydration condensation agent and retention agent in the synthesis of a variety of polymers and fine chemicals. It is widely used in dyes, photosensitive materials, liquid crystal display materials, aerospace technology, pesticides, pharmaceuticals, polymeric materials, etc, It has a very good development and application prospect to improve the speed of polymerization and the yield of products, and to be used as a derivative chemical reagent in the detection of toxic metabolites and bacteriocin in livestock meat, fruits and vegetables by gas chromatography and high performance liquid chromatography.