In chemistry, 2,2,5,5-tetramethyltetrahydrofuran or 2,2,5,5-tetramethyloxolane is a heterocyclic compound with the formula C 8H 16O, or (CH3)2(C(CH2)2OC)(CH3)2. It can be seen as derivative of tetrahydrofuran (oxolane) with two methyl groups replacing two hydrogen atoms on each of the carbon atoms in the ring that are adjacent to the oxygen. It can be seen also as a cyclic ether of 2,5-dimethylhexane, an isomer of octane. It is sometimes denoted by the abbreviations TMTHF or Me4THF.
The compound is sometimes used as a polar aprotic solvent in research chemistry and as a reagent in chemical synthesis.
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