Appearance:It is white or yellowish flake or columnar crystal, odorless, slightly bitter, and turns yellow when exposed to light and heat. Insoluble in water, slightly soluble in ethanol, easily soluble in chloroform and ether. Its solubility in sulfuric acid brine is large, and it is mostly made into injections.
Synopsis: Rotundine, also known as Rotundine and l-tetrahydropalmatine, with chemical name of 2,3,9,10-tetramethoxy-5,8,13,13a-tetrahydro-6h-dibenzo [a, g] quinazine, is a levorotatory substance of tetrahydropalmatine (DL THP). It is a blocker of dopamine receptor in the brain and preferentially blocks brain areas rich in dopamine receptors, such as cortex and striatum, It can achieve analgesic effect by strengthening the function of internal anti pain system and inhibiting the pivot in the transmission of pain information. Its analgesic effect is weaker than pethidine and stronger than general analgesics. It has no respiratory inhibitory effect under the therapeutic dose and does not cause gastrointestinal smooth muscle spasm. It has a certain effect on acute and chronic persistent pain and visceral dull pain. It was first listed in China in 1985. It is suitable for patients with insomnia due to pain. It can also be used for pain of gastric ulcer and duodenal ulcer, menstrual pain, uterine contraction pain after delivery, tension insomnia, spastic cough, etc.
Structural formula:
Properties
Summary
Rotundine, also known as Rotundine and l-tetrahydropalmatine, with chemical name of 2,3,9,10-tetramethoxy-5,8,13,13a-tetrahydro-6h-dibenzo [a, g] quinazine, is a levorotatory substance of tetrahydropalmatine (DL THP). It is a blocker of dopamine receptor in the brain and preferentially blocks brain areas rich in dopamine receptors, such as cortex and striatum, It can achieve analgesic effect by strengthening the function of internal anti pain system and inhibiting the pivot in the transmission of pain information. Its analgesic effect is weaker than pethidine and stronger than general analgesics. It has no respiratory inhibitory effect under the therapeutic dose and does not cause gastrointestinal smooth muscle spasm. It has a certain effect on acute and chronic persistent pain and visceral dull pain. It was first listed in China in 1985. It is suitable for patients with insomnia due to pain. It can also be used for pain of gastric ulcer and duodenal ulcer, menstrual pain, uterine contraction pain after delivery, tension insomnia, spastic cough, etc.
It is white or yellowish flake or columnar crystal, odorless, slightly bitter, and turns yellow when exposed to light and heat. Insoluble in water, slightly soluble in ethanol, easily soluble in chloroform and ether. Its solubility in sulfuric acid brine is large, and it is mostly made into injections.
Manufacturing
