Chemical name：(4R,6R)-Tert-Butyl-6-Cyanomethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetate
CAS NO：125971-94-0
Molecular formula：C14H23NO4
Molecular weight：269.33
Structural formula：
Application: Intermediate of Atorvastatin Calcium, a lipid-lowering drug.
Properties
Summary
Tert-butyl 2-[(4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate is used as an intermediate of atorvastatin. Atorvastatin is a selective competitive HMG CoA reductase inhibitor, which can significantly reduce LDL CH and triglyceride, but does not cause the redistribution of triglyceride, but constantly reduces TG in all lipoprotein components. It is suitable for the patients with primary hypercholesterolemia, heterozygous familial hypercholesterolemia or mixed hyperlipidemia, whose diet control can not effectively reduce the average total cholesterol, low density lipoprotein cholesterol and triglyceride. It is also suitable for patients with heterozygous familial hypercholesterolemia who have diet control at the same time.
Manufacturing
