2- (4- fluorophenyl) thiophene is an intermediate for the synthesis of cangreijing. The Canagliflozin, trade name Invokana, was the first approved sodium glucose co transporter 2 (SGLT2) inhibitor, which was approved by the US FDA in March 2013 for the treatment of type 2 diabetes. Canagliflozin is one of the best clinical antidiabetic drugs in recent years. 2 - (4-fluorophenyl) thiophene is an important intermediate in the synthesis of this compound. 2- (4- fluorophenyl) thiophene is an important intermediate for the synthesis of antidiabetic drug Canagliflozin, so it is necessary to purify 2-, 4- fluorophenyl thiophene. It is a white solid at room temperature and a liquid at heating condition. Therefore, it is difficult to separate and purify. The traditional column chromatography separation method is cumbersome, time-consuming and not conducive to industrial production. At present, the literature on the synthesis of this compound only mentioned the separation of this compound by column chromatography, but the operation of this method is cumbersome and not easy to industrial production.
Manufacturing
