Nimesulide is a non steroidal anti-inflammatory drug, which has high bioavailability, strong anti-inflammatory effect, antipyretic and analgesic effects, low toxicity and high therapeutic index. Clinically, it is mainly used for rheumatism, rheumatoid arthritis, osteoarthritis, respiratory tract inflammation, ENT inflammation, soft tissue and oral inflammation, as well as the accompanying fever, pain, etc. it can also be used for various postoperative pain and dysmenorrhea. Nimesulide has strong analgesic effect and rapid onset. It is faster and more effective in the treatment of oral pain than mefenamic acid and placebo in comparable doses; It is more effective for acute pain than non steroidal anti-inflammatory drugs, and has better gastrointestinal tolerance; Compared with the commonly used non steroidal anti-inflammatory drugs, the curative effect of non steroidal anti-inflammatory drugs is equivalent or better in soft tissue injury, extraarticular trauma, various kinds of ear nose throat inflammation and dental surgery.