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International non-proprietary name (INN): Hydroxyethyl Starch 130/0.4
Synonyms: HES, Hydroxyethyl starch, Tetrastarch , Hydroxyethylated amylopectin,
2-Hydroxyethyl starch, 2-Hydroxyethyl starch ether
Chemical name: Poly (O-2-hydroxyethyl) starch (130/0.4)
CAS No.: 9005-27-0
Hydroxyethyl Starch 130/0.4 is characterized by its molar substitution and also by its molecular weight. Its molar substitution is approximately 0.40 which means Hydroxyethyl Starch has an average of approximately 40 hydroxyethyl groups for every 100 glucose units. The weight average molecular weight is approximately 130,000 with a range of 110,000 to 150,000. HES 130/0.4 IV solution is one of the most frequently used HES. Rapidly degradable medium MW HES 130/0.4 are quickly split in vivo into smaller, more favorable molecule sizes, quieter renal elimination, more appropriate volume effect, and fewer adverse effects on coagulation and rheological parameters.
Manufacturing
