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Stearic Acid | |||
Product model | Stearic acid content (%) | freezing point | Purpose and characteristics |
ZW-S50 | ≥40% | 53～59℃ | Suitable for lubrication and bonding of most preparations |
ZW-S70 | ≥60% | 57～64℃ | It is suitable for cream matrix and preparations with special requirements for freezing point |
ZW-S95 | ≥90% | 64～69℃ | It is suitable for eutectic extrusion process and has special requirements for freezing point |
*The prospect is based on the specific physical properties of stearic acid to improve the specificity and improve the influence of preparations with new requirements on freezing point.
Application in pharmaceutical preparation or preparation technology
Preparation use | Recommended dosage (%) |
Ointment or cream | 10~20 |
Solid lubricant | 0.5~2 |
Functional features and main uses
◎ stearic acid is widely used in oral and external pharmaceutical preparations, as well as cosmetics and food. Stearic acid is a non-toxic and non irritating substance.
◎ mainly used as lubricant for tablets and capsules; Stearic acid is used as emulsifier and solubilizer in topical preparations.
Solid preparations, lubricants, adhesives
◎ to be used as lubricant for tablets and capsules, or as adhesive
◎ combined with insect glue for tablet coating
◎ it can be used for enteric coated tablets coating and sustained-release preparation carrier
Topical emulsifier and solubilizer
◎ stearic acid partially neutralized with alkali or Triethanolamine can be used for cream preparation
◎ partially neutralized stearic acid is added with 5 ~ 15 times aqueous liquid to form cream matrix
◎ it can be added to glycerol suppository as hardener
Special uses and taboos of the product
◎ due to its certain hydrophobic type, it can be used as a release or slow-release material in solid preparations.
◎ in some co melt extrusion processes, a large amount of stearic acid is used as the matrix.
◎ compatibility: the ointment matrix made of stearic acid mixed with zinc salt or calcium salt will lead to drying or caking. When stearic acid is used in tablet coating by aqueous film coating technology, it will cause coating pitting, and its melting point is the cause of this defect.
◎ literature suggests that stearic acid and naproxen have incompatibility, and stearic acid and most metal oxides, bases, reducing agents and oxidants have incompatibility.
◎ the potential application of stearic acid is in the preparation of "buffer particles" composed of stearic acid and microcrystalline cellulose. It is composed of stearic acid: microcrystalline cellulose (4:1w / W). In the compression step of the manufacturing process, the rupture of the outer coating of the pellets can be avoided.
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