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Highlights of Holypharm Ectoin/Ectoine:
▶ Functional indicators: Conductivity below 5%, light transmittance 99.9% Min, almost the highest level in China.
▶ Appearance: Produced by biosynthesis process, without residual solvent, and with the uniform crystal form.
▶ Annual capacity: Class of 100 tons, large quantity in stock, prompt delivery after order, no need to wait.
▶ Technical advantage: own the exclusive Ectoine strain and production patent of the Chinese Academy of Sciences, higher bio-activity, safer for humans. Most domestic manufacturers have technical advantage barriers to production after purchasing our patents.
▶ Competitive Price: Cost and technology advantages lead to competitive prices, lower 30% price than market price.
Product Name: | Ectoine | CAS No.: | 96702-03-3 |
Other Names: | Ectoin; L-Ectoine; Thp(B); Tetrahydropyrimidine; | Application: | Cosmetics; Anti-aging fermented; Moisturizing agent; Humectant; |
Purity: | ≥98.5% | Grade Standard: | Cosmetic Grade |
Appearance: | White or white like crystal or powder | Place of Origin: | China |
Application: | With the function of moisturizing and repairing, Ectoine is widely used in the field of skincare products and can be used to improve skin color. | ||
130 Metric Tons per Year
Packaging Details: | 25 KG / Drum |
Port: | Shanghai Port, or other main ports in China |
Items | Specifications | Results |
Appearance | White or white like crystal or powder. | Conforms |
Sectrographical Identification | The infrared absorption spectrum should be consistent with the reference spectrum. | Conforms |
Assay(HPLC) | ≥98.5% | 99.70% |
Specific rotation | +139°-+145° | +141.3° |
PH | 6.0-8.0 | 6.75 |
Light transmittance of the solution | ≥98.0%(430nm) | 99.80% |
Solvent residue | Methanok<10ppm | Conforms |
Ethanol<2000ppm | Conforms | |
Chloride | ≤0.03% | <0.03% |
Loss on drying | ≤0.5% | 0.07 |
Residue on ignition | ≤0.1% | 0.01% |
Heavy metals | As≤2ppm | <2ppm |
Pb≤10ppm | <10ppm | |
Sb≤1ppm | <1ppm | |
Cd≤5ppm | <5ppm | |
Ni≤10ppm | <10ppm | |
Cr≤5ppm | <5ppm | |
Hg≤1ppm | <1ppm | |
Total plate count | ≤100CFU/g | Conforms |
Yeast& mold count | ≤50CFU/g | Conforms |
Staphylococcus aureus | No detection | Negative |
Pseudomonas aeruginosa | No detection | Negative |
Thermtolerant coliforms | No detection | Negative |
Conclusion | Conform to standard | Conforms |
Holypharm Biotech is a company that uses the latest biosynthetic technology to produce the latest international cosmetics raw materials, nutritional ingredients, and preparations. The company is co-founded by business elites and brilliant scientists with strong academic backgrounds. We use synthetic bio-engineering technologies to provide innovative manufacturing solutions.
Through systematic engineering at the level of molecular (DNA manipulation, direct evolution of enzymes, etc.), cellular and sub-cellular (metabolic network rewriting and compartmentalization), and culturing (fermentation optimization), we manage to commercialize our designed microbial cell factories for large-scale bio-manufacturing of various products.
Supported by our professional expert team and outstanding GMP system, Holypharm offers Contract Research and Manufacturing (CRAM) services for active pharmaceutical ingredients (APIs) from synthesis and fermentation that cover all therapeutic areas.
Two solutions for our CRAM Services:
1. Produce APIs according to the dossier provided by customers.
2. Develop and optimize the manufacturing process from lab to commercial when a customer has limited techniques on target products.
We here guarantee that any inquiries from our customers and all projects undertaken by Holypharm will be kept confidential or protected by nondisclosure agreements if it is necessary.
▶ We have our GMP standard plants in Jiangsu and Zhejiang provinces, and 68 researchers in the R&D center in Wuhan and Tianjin. Moreover, we also have a close relationship with labs from the top 10 Chinese research institutes.
▶ We have expanded our business worldwide covering the major pharmaceutical markets, especially US and EU where our representative offices are located. Attributing to the efforts of our regulatory affairs (RA) experts, we are participating in the registration of several promising APIs in the US and EU as well as cooperating with Novartis, CHEMO, and Merck.
▶ We hold the gold relationship with both domestic and foreign pharmaceutical manufacturers, we are adept in re-arranging and co-ordinating their supply and demand on formulations to build up an excellent pipeline system that will benefit all the worldwide healthcare welfare.
Ectoin is an amino acid derivative, a multifunctional active ingredient of extreme enzyme component, which can prevent and prevent cell damage, and also provide repair and regeneration effects for cell aging and transitional tension and irritation skin. In 1993, Bitop, a German biotechnology company, was founded and carried out research on the extraction and production technology of Iketoine. Later, Bitop cooperated with Mercadon, a German pharmaceutical company, to produce Iketoine by fermentation. At present, it has been used in enzyme preparation, biological medicine, skin care products and other related fields.
Because Ectoine comes from Halomonas Elongata, it is also called "salt tolerant bacteria extract". Under the extreme conditions of high salt, high temperature and high ultraviolet radiation, the halophilic bacteria are protected from damage by Ectoine. Studies have shown that Ectoine also has a good repair and protective effect on the skin. Ectoin is a 100% natural active ingredient of multifunctional safety cosmetics, which has the anti-aging property of comprehensively protecting the nucleus. Ectoin is one of the bioengineering agents used in high-end cosmetics.
1) Cosmetics industry: Ectoin has significant protective, anti-stress and anti-aging effects in skin care, helping skin resist external pressure, and can be widely used in personal care products such as repair, anti-pollution, sunscreen, post-sun repair, anti-aging, etc.
2) Pharmaceutical industry: Ectoin can be used for eye drops, nasal sprays, oral sprays, etc. It can be used for the treatment of eczema, and neurodermatitis, and is approved for the treatment of inflammatory and atopic baby skin.
Ectoine can protect halophilic bacteria from harm.
▶ Functional indicators: Conductivity below 5%, light transmittance 99.9% Min, almost the highest level in China.
▶ Appearance: Produced by biosynthesis process, without residual solvent, and with uniform crystal form.
▶ Annual capacity: Class of 100 tons.
▶ Technical advantage: Buy out and own the exclusive Ectoine strain and production patent of the Chinese Academy of Sciences. Most domestic manufacturers have technical advantage barriers to production after purchasing our patents.
Ectoine is a natural and effective cosmetic active ingredient. Since Ectoine has a wide range of cytoprotective functions, it can be applied in cosmetic products with a variety of different functions. Etomoxir has moisturizing, antioxidant, protective photoaging, sun protection, and other effects.
Pretreatment of skin with Ectoin can reduce skin damage caused by dehydration; One molecule of Ectoine can complex four or five water molecules, which can make the free water in cells structured. Compared with glycerin, Ecoin is more moisturizing to the skin.
Relevant data shows that Ectoine can continuously improve the skin's moisturizing and water-holding capacity during the application period, and the skin's water-holding capacity will not decline immediately after discontinuation. The skin's water-holding capacity is still higher than that of the control group after one week of discontinuation.
There are clinical trials showing that etomoxir prevents the weakening of the antioxidant capacity of cells with increasing age, with a certain antioxidant capacity.
The experimental data showed that 0.1mmectoine, 0.5mm maltathionine and 1.5mm mannitol were mixed to reduce DNA single-strand breaks in human glial cells under 400-800 nm light source and reduce the intensity of ROS oxidative reaction, which may reduce skin oxidative damage by light.
Ectoine can simply and effectively prevent stress factors from damaging cells, and isolate damage caused by ultraviolet radiation, pollutants, allergens, cold and hot alternations, drying, or chemical stimulation. At the same time, it can protect the skin from the influence of cell aging and has become an important active ingredient against skin aging.
Langerhans cell in the epidermis play a key role in the cutaneous immune system, but it is exquisitely sensitive to UV stress. Ectoine happens to keep this Langerhans cell population from decreasing in response to UV radiation, allowing the skin's immune system to maintain its proper functioning.
In the external environment, ultraviolet radiation, high temperature, hypoxia, viral infection, heavy metals, air pollution and other factors can cause cell damage, while Ectoine can produce emergency protection response and regeneration response, and generate heat shock protein to help each cell maintain normal physiological activities.
The functional role of Ectoine cannot be ignored. In some products with more "acids" or "antioxidants", in order to increase skin tolerance, we will consider using Ectoine to help skin reduce sensitivity and irritation when obtaining benefits.
Aging of the skin is not only the result of time-lapse, one of the important external factors is UV light, especially UVA (320-400 nm). UVA wavelengths have the lowest energy throughout the UV spectrum, but unlike UVB, the variation in UVA content in sunlight is little affected by latitude, time period, weather, and season, such that the daily, annual exposure dose to UVA is almost fixed and is continuously and massively accumulated throughout our lifetime.
The mainstream manufacturers on the market all adopt the biosynthesis method, but Holypharm Biotech strains are directly supplied by the Chinese Academy of Sciences and have been enlarged and improved, and the yield and quality are superior to those of our peers in all aspects.
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We are a manufacturer that owns GMP factories both in Jiangsu and Zhejiang Province. They cover an area of about 2000 mu. You are warmly welcome to visit us!
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