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Product Name: | β-Nicotinamide Mononucleotide | CAS No.: | 1094-61-7 |
Other Names: | Beta-Nicotinamide Mononucleotide; nicotinamide mononucleotide; | Certificates: | USP; GMP; Kosher |
Abbreviation: | NMN; β-NMN | Type: | Pharm Grade |
Appearance: | White Powder | Assay(HPLC): | ≥99% |
Yinfu Medicine has carried out a phase I clinical experiment with a population size of up to 66 people. Through double blind, control group, repeated dose and other experimental settings ® Security provides strong endorsement.
Shanghai Yinfu Pharmaceutical is the only NMN raw material manufacturer with both mature enzymatic process and synthetic process, to meet the needs of different markets and brands, Yinfu Pharmaceutical provides high-quality NMN raw materials made by different processes, a complete self inspection and third-party inspection report shall be provided to fully guarantee the safety of the product).
The production department strictly controls impurities, with single impurities not exceeding 0.5% and total impurities not exceeding 1%, including NR and nicotinyl. Amine, ribose, heavy metals and microorganisms are also strictly controlled within the safety scope of the USP standard.
In order to improve the internal stability of NMN, researchers analyzed the structure of NMN and used the charge transfer
It is found that the NMN has an inner salt structure and the isoelectric point of the inner salt is the instability of the NMN
The key factors to determine. As a result, researchers have creatively developed an orderly and compact spherical crystal
Learning NMN -- the second generation NMN. This compact and orderly structure effectively blocks the freedom of NMN and air. The contact with water greatly improves the stability of NMN and extends the shelf life of products.
Microarray ordered and dense NMN has higher bulk density and better fluidity, avoiding the preparation process. Due to the increase of dust, the dosage is unstable, the packaging loss is large, and the equipment cleaning is difficult. Same asthe second generation NMN has good liquidity, which helps to shorten the production cycle and reduce, manufacturing cost and difficulty, improve packaging accuracy.
NMN is popular to use on its own and is often marketed by supplement brands towards anti-aging and general wellness markets. We also believe there are applications for this in energy supplements, workout enhancement, blood sugar control, and even weight loss, but we leave it to you to formulate fantastic products – we simply provide the key to the engine with the best NMN on the market.
In this post, we’ll break down all that goes on within the body in regards to aging – what happens in the cells, the mechanisms at play, and the bioactive substances that facilitate it. We’ll then explain the potential NMN offers in reducing these effects of aging, as well as why it’s a better option than some other alternative solutions!
Nicotinamide mononucleotide(NMN), a derivative of niacin, is a nucleotide that functions as a precursor to nicotinamide adenine dinucleotide (NAD+). NAD+ is a molecule that holds a variety of functions within the body, mainly through the facilitation of cell-signaling enzymes called sirtuins. These enzymes are crucial for normal functioning, with SIRT1 (there are 7 sirtuins) being particularly unique. Research has shown it to be highly active following caloric restriction, which itself brings multiple benefits, including signs of an extending lifespan. Sure enough, further tests have revealed that elevated levels of SIRT1 can lead to protection from metabolic decline and disease.
These sirtuins mainly operate through the mitochondria. They act as “message carriers” of sorts – when cell nuclei send signals to the mitochondria, sirtuins (SIRT1 specifically) help make sure the message gets there[5]. We all know how vital proper mitochondrial function is – they aren’t called the “powerhouse of the cell” for nothing! Because sirtuin activity is directly dependent on NAD+ levels[2], NAD+ becomes incredibly important, too!
Research has shown that NMN helps protect from ischemia[9], a result of insufficient blood flow in anyarea of the body. Typically, the body defends itself from ischemia via ischemic preconditioning (IPC)[10]. IPC stimulates SIRT1, which is a NAD+ dependent sirtuin[9], which helps move blood throughout the body. Because NMN activates SIRT1, then, it has the ability to mimic IPC, and thus is capable of protecting the heart from ischemia and reperfusion[9]!
Efficient circulation is, obviously, crucial to overall well-being. Specifically, having adequate blood flow is imperative in brain health. Without enough oxygenated blood reaching our brain, serious issues can arise.
Luckily, NMN helps ensure that this essential organ gets all the oxygen it needs. Improper mitochondrial functioning is a known precursor of neurodegenerative diseases, such as Alzheimer’s. Having hard-working, healthy mitochondria can help fend off these kinds of diseases. Research shows that because NMN increases NAD+, which increases the degree of healthy mitochondria functioning, it has the potential to be a protective agent against neurodegenerative disease[11].
Despite how diligent one is in their eating habits, the risks of obesity and diabetes have never been higher than they are in today’s society. Calorically-dense processed foods, in addition to foods and industrialized seed oils with negative nutritional value, are more common than healthy alternatives anymore! Just as consistently-elevated blood sugar and Hypoglycemic hormone levels lead to diabetes, continuous overeating will eventually lead to weight gain. Our metabolisms are well-oiled machines, but unless we ensure they are functioning properly, bad habits can ultimately cause them to falter.
With multiple metabolic pathways operating throughout the body, a lot of different components are involved in keeping adequate metabolic health. One of which is facilitated by nicotinamide phosphoribosyltransferase (NAMPT), which we mentioned earlier is an enzyme dependent on NAD+. In 2011, the ability of NMN supplementation to fix NAMPT deficiencies in diabetic mice was tested. Researchers found that NMN stimulated NAD+ biosynthesis, raising NAD+levels in the pancreas, liver, and white adipose tissue[12]. With the pancreas being directly responsible for the secretion of insulin, which keeps blood sugar levels regulated, one can hypothesize that this would help protect from diabetes. Sure enough, that’s what this study found! NMN was found to decrease the effect of underlying causes of diabetes and significantly improve glucose tolerance[12], both of which help protect from diabetes and obesity.
The extra baggage that comes along with getting older, quite plainly, is pretty heavy. Being more susceptible to pains and aches and having less energy, all while your metabolism is screeching to a stop, is something that no one looks forward to. But, as current science stands, it remains an inevitability. However, that doesn’t mean there isn’t a way to slow this deterioration down!
Most of the symptoms of aging are directly related to how well our mitochondria are working. These powerhouses run on a specific fuel called NAD+, and this energy source seems to grow harder to find as we get older. Without it, we produce less ATP, and our bodies start to become liable to a variety of diseases and undesirable symptoms.
In EffePharm’s NMN, we are providing you the best way to keep NAD+ production in high-gear. Using NMN boosts both NAD+ production and cellular activity, both of which are needed to keep you feeling like a well-oiled machine.
How often have you watched your children, or your grandchildren, run around tirelessly for hours and thought,“Wow, I wish I had that kind of energy?” Well, with our natural anti-aging energy enhancer, you may just be able to get up and run around with them… at least for a little bit!
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