5-Flucytosine

Quality standard

Molecular formula: C₄H₄FN₃O
Molecular weight: 129.09
CAS: 2022-85-7
Potential of Hydrogen	5.5-7.5
Related Substances	Fluorouracil ≤0.2%
Related Substances	Other Impurities <1.0%
Ash Residueon Ignition	≤0.2%
Heavy Metal	≤20pmm
Loss on Drying	≤0.5%
Puer(HPLC)	≥99%

Character:

white or almost white crystal powder, odorless or light smell; lightly soluble in water and ethyl alcohol; nearly insoluble in chloroform and diethyl ether; easily soluble in diluted hydrochloric acid and diluted diluted hydrochloric acid; stable under room temperature

To use:

As antifungal agents; for mucocutaneous candidiasis disease, candida endocarditis, candida arthritis, cryptococcal meningitis and chromoblastomycosis;

Storage:

Should be preserved in cool and dry place in closed container

Transportation:

As common chemicals

Properties

5-fluorocytosine (5-FC), also known as 5-fluorocytosine, 5-fluorocytidine, anjezhi, and anlapen, is a white or quasi white crystalline powder. The inhibitory effect of 5-fluorocytosine on fungi is due to its entering into the cells of sensitive fungi, and under the action of cytosine deaminase, 5-fluorouracil, an anti metabolite, is formed. The latter is converted to 5-fluorouracil-2-deoxyriboside, which inhibits thymidine synthase, blocks the conversion of 5-fluorouracil-2-deoxyriboside to thymidine, and affects DNA synthesis. It has a good inhibitory effect on Candida, Cryptococcus and hyphomycetes, and also has an effect on some Aspergillus, as well as mycospores and bottle fungi which cause skin fungal diseases.

CAS No.

2022-85-7

Formula

C4H4FN3O

Molecular Mass

129.09200

Exact Mass

129.03400

PSA

71.77000

Logp

0.07240