2-Cyanopyrimidine

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2-Cyanopyrimidine

CAS NO.： 14080-23-0

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Specification： 99%

Documentation： Get COA after inquiry

Lead Time： 14-30 days

Max Capacity： -

Packing： 25KG/Fibre Drum

Product Detail

Properties

2-Cyanopyrimidine

Product Name: 2-Cyanopyrimidine

CAS NO：14080-23-0

Molecular formula: C5H3N3

Molecular weight: 105.09

Appearance: white to yellow powder

Application: pharmaceutical intermediate, bosentan intermediate

Properties

2-Cyanopyrimidine is a key intermediate in the synthesis of bosentan. Bosentan is a kind of drug for the treatment of pulmonary hypertension, which is suitable for the treatment of patients with pulmonary hypertension (PAH) of who functional classification II-IV (who group 1), in order to improve the exercise ability of patients and reduce clinical deterioration. Studies supporting the effectiveness of this product mainly included patients with idiopathic or hereditary PAH (60%) of who functional classification II-IV, PAH associated with connective tissue disease (21%) and PAH associated with left to right shunt congenital heart disease (18%).

CAS No.

14080-23-0

Formula

C5H3N3

Molecular Mass

105.09700

Exact Mass

105.03300

PSA

49.57000

Logp

0.34828

IUPAC

pyrimidine-2-carbonitrile

Matter Classification

organic

Category

Melting Point

40-44 °C(lit.)

Density

1.22 g/cm3

Boiling Point

250.7ºC

Flash Point

>230 °F

Appearance

White to Yellow Crystalline Powder

Acidity and Basicity

alkalinity

HS Code

29335990

UN No.

3276

Risk Code

R22-37/38-41-43-34-11-25

Safety Label

Xn,C,F,T

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2-Cyanopyrimidine