Niclosamide

Chemical Name:	2',5-dichloro-4'-nitrosalicylanilide
Molecular Formula:	C₁₃H₈Cl₂N₂O₄
Molecular Weight:	327.119
CAS No.:	50-65-7
Chemical Structure:
Specification:	EP/CP(V)
Pharmacodynamic Properties:	Niclosamide is a lampricide and molluscicide. It kills a wide variety of snails, cestodes（Taenia saginata and Taeniasolium) and Cercariae by affecting the respiration and the carbohydrate metabolism. It probably disturbs oxidation processes by inhibiting oxygen uptake. The main target pest in agricultural use is the golden apple snail (Pomacea canaliculata) in paddy fields (rice-cultivation). It is also used in public health for control of snails which are the intermediate hosts of Schistosoma spp., the infectious agents of schistosomiasis. The compound is quickly metabolized in water and does not exhibit a long-term effect (Andrews et al, 1983). It is also applied to commercially managed fish ponds, in order to clean them from undesirable fish prior to re-filling the pond. Niclosamide is highly toxic to fish but, due to its short half-life in water, the batch of new fish may be added only a few days after application of the pesticide.

Properties

Niclosamide is a kind of cestode repellent with low toxicity. It has high curative effect on many kinds of cestodes. The mechanism of cestode is to block the cycle of tricarboxylic acid of cestodes and make lactic acid accumulate and cause the death of cestodes. It is the first choice for the prevention and treatment of cestodiasis in livestock, poultry and pets. It has a strong insecticidal effect on Taenia saginata, Taenia saginata and Taenia saginata. Low concentration of the drug can promote the uptake of oxygen, while high concentration can inhibit the oxidative phosphorylation reaction of mitochondria, hinder the absorption and uptake of glucose, resulting in the death of scolex and proximal segment of cestode, which falls off from the intestinal wall and is excreted with feces. It can also be used to kill oncomelania, oncomelania eggs, cercaria and miracidia. It has high molluscicidal rate, slow action and long residual effect. It can be used to prevent schistosomiasis, and the effect is better when the temperature is above 20 ℃. In addition, this product is harmless to people, livestock and plants, and highly toxic to fish, so it is forbidden in fish ponds.

CAS No.

50-65-7

Formula

C13H8Cl2N2O4

Molecular Mass

327.12000

Exact Mass

325.98600

PSA

95.15000

Logp

4.45570