(4R,6R)-Tert-Butyl-6-Cyanomethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetate

Home > API & Intermediate > Pharmaceutical Intermediates > (4R,6R)-Tert-Butyl-6-Cyanomethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetate Manufacturers > ATS-8: (4R-cis)-1,1-Dimethylethyl-6-Cyanomethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetate

CAS NO.： 125971-94-0

FOB Price： NEGOTIABLE Get Latest Price

Specification： 99.5%

Documentation： Get COA after inquiry

Lead Time： 14-30 days

Max Capacity： -

Packing： 25KG/Fibre Drum

Product Detail

Properties

ATS-8: (4R-cis)-1,1-Dimethylethyl-6-Cyanomethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetate

Chinese name：ATS-8:(4R-Cis)-6-氰甲基-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯；阿托伐他汀钙中间体ATS-8

CAS NO：125971-94-0

Molecular formula：C₁₄H₂₃NO₄

Molecular weight：269.34

EINECS NO：425-780-3

Melting point：65-69 °C(lit.)

Boiling point：364.1±17.0 °C(Predicted)

Density：1.016±0.06 g/cm3(Predicted)

Application：Atorvastatin calcium intermediate

Properties

Tert-butyl 2-[(4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate is used as an intermediate of atorvastatin. Atorvastatin is a selective competitive HMG CoA reductase inhibitor, which can significantly reduce LDL CH and triglyceride, but does not cause the redistribution of triglyceride, but constantly reduces TG in all lipoprotein components. It is suitable for the patients with primary hypercholesterolemia, heterozygous familial hypercholesterolemia or mixed hyperlipidemia, whose diet control can not effectively reduce the average total cholesterol, low density lipoprotein cholesterol and triglyceride. It is also suitable for patients with heterozygous familial hypercholesterolemia who have diet control at the same time.

CAS No.

125971-94-0

Formula

C14H23NO4

Molecular Mass

269.33700

Exact Mass

269.16300

PSA

68.55000

Logp

2.54208