Berberine hydrochloride has been used in clinic for a long time as antipyretic and antibacterials. Berberine hydrochloride has inhibitory effect on Shigella dysentery, Escherichia coli, Diplococcus pneumoniae, Staphylococcus aureus, Streptococcus, typhoid bacillus and Amoeba protozoa. It is commonly used in the treatment of bacillary dysentery, acute gastroenteritis, chronic cholecystitis, conjunctivitis, suppurative otitis media and other diseases, and has significant curative effect. Berberine hydrochloride is an isoquinoline alkaloid, which exists in many plants such as Berberidaceae.