API & Intermediate

Tert-butyl 2-[(4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate is used as an intermediate of atorvastatin. Atorvastatin is a selective competitive HMG CoA reductase inhibitor, which can significantly reduce LDL CH and triglyceride, but does not cause the redistribution of triglyceride, but constantly reduces TG in all lipoprotein components. It is suitable for the patients with primary hypercholesterolemia, heterozygous familial hypercholesterolemia or mixed hyperlipidemia, whose diet control can not effectively reduce the average total cholesterol, low density lipoprotein cholesterol and triglyceride. It is also suitable for patients with heterozygous familial hypercholesterolemia who have diet control at the same time.

Ulinastat acetate is a new oral emergency contraceptive, and the efficacy of emergency contraception will not decline with the delay of medication time. At the same time, it has good safety and tolerance.

Pyruvate is a component of human body, which is mainly involved in the metabolism of sugar and fat in human body, and is also one of the intermediate products of carbohydrate metabolism. Pyruvic acid and its salt are widely used in medicine field, and are used to produce tranquilizers, antioxidants, disease resistant agents, synthetic drugs for hypertension and so on. Pyruvic acid can be used in the synthesis of medicine and amino acids, which can improve the production efficiency, especially in pharmaceutical industry, it can shorten the process and simplify the process. For example, 2-phenyloctenic acid, which is made of this product, is a kind of antipyretic and analgesic and diuretic drug. Using this product as raw material can greatly reduce the production cost. It is also used as the anti tuberculosis drug, calcium isoniazide pyruvate, hormone synthesis, pyreniumapamote as an insecticide, and also as pesticide raw materials. The tryptophan can be produced by biochemical reaction from pyruvic acid, indole and ammonia, and it can also be used to produce MSG and spices.

Milbeoxime is a macrolide antibody endoparasite and an oxime derivative of milbemycin A3 and A4. Milbeoxime can bind glutamate gated chloride channels and act on intestinal nematodes, lung and heart worms. Milbeoxime has a broad spectrum of antiparasitic effects, and has good repellent and killing effects on internal and external parasites, especially nematodes and arthropods.

Riboflavin sodium phosphate is a prodrug of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). It is also known as vitamin B2 sodium phosphate, flavin mononucleotide sodium and riboflavin-5 '- (dihydrophosphate) monosodium salt in Chinese. FMN and fad are important cofactors of flavinase family. Flavinases catalyze many biochemical reactions, the most typical of which is redox reaction. They are the key factors of cell respiration.