Biochemicals

It is a soluble interleukin receptor fusion protein developed by Regeneron Corporation, which can block the inflammatory response signaling pathway of interleukin. The researchers first conducted a 6-week small-sample clinical trial of linacept in the treatment of chronic gout, and found that linacept can effectively control inflammation, reduce pain and inflammation on joints, and have mild adverse reactions. A single subcutaneous injection of linacept 320 mg reduces pain and adverse effects of acute gout attacks compared with the highest dose of a non-steroidal anti-inflammatory drug (indomethacin, 50 mg three times a day for 3 days) the occurrence of the reaction.

Fenneridone is a new type of mineralocorticoid receptor antagonist, which can delay the progression of chronic kidney disease. Some people may be aware of two other mineralocorticoid receptor antagonists: diuretics, antihypertensive drugs, spironolactone, and eplerenone. Non neridone is their sibling, and the third generation of mineralocorticoid receptor antagonist just came out after them.

Sotovizumab is a pan sarbecovirus monoclonal antibody designed to prevent the progression of covid-19 in high-risk patients early in the course of the disease.

Propidium Iodide is a fluorescent nucleic acid dye which binds only to double-stranded nucleic acids. It has a molecular weight of 668.4, an absorbance maximum of 535nm, and an emission maximum of 617 nm. It is commonly used to determine the DNA content of a cell or to discriminate viable from non-viable cells.

Total acetyl sugar generally refers to sugar derivatives in which all free hydroxyl (- OH) or amino (- NH2) in sugar molecules are protected by acetyl (- AC). Such molecules are an important synthetic intermediate in organic synthesis. Total acetyl sugar refers to sugar derivatives in which all free hydroxyl (- OH) or amino (- NH2) in sugar molecules are protected by acetyl (- AC). For example, 1,2,3,4,6-o-pentaacetyl-d-glucopyranose (galactose, mannose) is common in the laboratory. It is widely used in many fields, such as sugar biology, sugar chemistry, synthetic chemistry, pharmaceutical chemistry, material science, physical chemistry and so on. For example, diacetyl glucose is a potential surfactant; In the synthesis of sugar molecules as raw materials, the preparation of total acetyl sugar is often the first step to protect the exposed hydroxyl groups, which is of great significance for the follow-up reaction. Due to the wide application of total acetyl sugar in chemical experiments, the reagents such as total acetyl glucose, mannose and lactose prepared by the factory can be ordered directly on the market. However, for less experimental dosage, it is common to use the original sugar molecules to prepare acetyl sugar temporarily in the laboratory. At the same time, the total acetylation of monosaccharides such as glucose involves the preparation of chiral compounds, the application of thermodynamic and kinetic control theory, the influence of sugar end group effect on the product configuration, the influence of different catalysts on the product configuration ratio, as well as the basic experimental operations such as vacuum filtration, extraction and recrystallization. Therefore, learning to prepare total acetylsaccharides is of great significance for understanding the organic reaction mechanism and training the basic operations, It can be used as a good teaching content of College organic chemistry experiment course.