Biochemicals

Ampelopsin, also known as dihydromyricetin, is a flavanonol, a type of flavonoid. It is found in the Ampelopsis species japonica, megalophylla, and grossedentata; Cercidiphyllum japonicum; Hovenia dulcis; Rhododendron cinnabarinum; some Pinus species; and some Cedrus species, as well as in Salix sachalinensis. Hovenia dulcis has been used in traditional Japanese, Chinese, and Korean medicines to treat fever, parasitic infection, as a laxative, and a treatment of liver diseases, and as a hangover treatment. Methods have been developed to extract ampelopsin from it at large scales, and laboratory research has been conducted with the compound to see if it might be useful as a drug in any of the conditions for which the parent plant has been traditionally used. In a trial of sixty patients with fatty liver disease dihydromyricetin improved glucose and lipid metabolism and exerted anti-inflammatory effects which were beneficial.

Citicoline is a kind of nucleic acid derivative. In 1956, Geiger found that citicoline can make brain injury recover; Kennedy's research in 1957 confirmed that it was very important in the synthesis of brain phospholipids. In 1961, Takeda pharmaceutical company of Japan developed and produced this product, which was registered in China in 1988. It plays an important role in the synthesis of lecithin and improves brain function by promoting the synthesis of lecithin. Experiments have shown that citicoline can enhance the levels of norepinephrine and dopamine in the central nervous system, so as to treat cerebrovascular disease, brain trauma and cognitive impairment caused by various reasons, and has no obvious side effects. Citicoline sodium can enhance the brain stem reticular formation, especially the ascending reticular formation closely related to consciousness, activate the function of the system, enhance the role of the pyramidal system, inhibit the role of the extrapyramidal system, and promote recovery. At the same time, it can reduce cerebral vascular resistance, increase cerebral blood perfusion and promote cerebral material metabolism. It is mainly used in the treatment of neurological sequelae caused by brain injury and cerebrovascular accident, and can be used in the treatment of Parkinson's disease, and has certain curative effect on Alzheimer's disease; For the treatment of cerebrovascular and cardiovascular diseases; Others, such as delaying aging, improving learning effect and memory, also have certain curative effect.

It can be used as seasoning. It can be used as an adjuvant for liver disease. It can be used as intermediate of nucleic acid medicine, health food and biochemical reagent.

This product is suitable for protecting the abnormal metabolism of myocardium under the condition of myocardial ischemia.

N-acetyl-dl-leucine is mainly used as pharmaceutical intermediate, biochemical reagent, resolution reagent, etc.