Hormones and Endocrine Drugs

This product is a kind of glucocorticoid with anti-inflammatory, anti allergic, anti toxin and anti shock effects.

Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations.

Dehydroepiandrosterone (DHEA), chemical name is 3 – β– Hydroxyandrosterol – 5 – ene – 17 – one is a kind of cholesterol retaining △ 5,6 double bond and esterifiable 3 – β– The hydroxyl steroid has a molecular formula of C19H28O2, a molecular weight of 288.41, a melting point of 151 to 153 degrees centigrade, and an optical rotation of +5.5 degrees. It is an precursor of adrenal gland hormone secreted by the adrenal cortex reticular layer of the human body. It has the physiological functions of regulating obesity, preventing diabetes, resisting cancer and virus infection, improving memory, immune reaction and stress reaction, and reducing tension. It is an intermediate for the manufacture of steroid hormones and participates in the synthesis of adrenal glands to secrete a variety of hormones.

Dexamethasone sodium phosphate belongs to adrenocortical hormone drugs, which can stabilize lysosomal membrane and reduce the release of lysosomal hydrolase; It can inhibit the production of bradykinin, 5-hydroxytryptamine and prostaglandin, increase the stability of mast cell granules and reduce the release of histamine; Constrict blood vessels, inhibit the migration of leukocytes and macrophages outside blood vessels, so as to have anti-inflammatory effect. It can exert immunosuppressive effect by inhibiting the function of macrophages. It can inhibit the formation of fibroblasts, prevent corneal scar, reduce scar formation and protect vision when used in trauma. It can inhibit or reduce the formation of neovascularization in corneal and conjunctival diseases. Local application can reduce rejection and scar formation in corneal transplantation and myopic surgery. It is clinically used for the treatment of autoimmune diseases, allergies, inflammation, rheumatism, asthma, ophthalmology and dermatology.

Dinogestrin is a newly listed selective luteal hormone drug in recent years. It can play a role in stabilizing endometrial tissue by specifically binding ethylene nortestosterone and progesterone derivatives. It has been found that tumor necrosis factor (TNF). And interleukin-8 (IL-8) increased in patients with endometriosis.