Pharmaceutical Intermediates

It is a pharmaceutical intermediate for the synthesis of new sartan antihypertensive drugs, such as losartan, valsartan, ipsartan, irbesartan, etc.

Pentaerythritol, as a quaternary alcohol, is easy to be esterified to form acids and esters, so it is mostly used as raw material of alkyd resin coatings, mainly used as building coatings and automotive primer. Pentaerythritol tetranitrate can be obtained by esterification of pentaerythritol and concentrated nitric acid at 5 ~ 15 ℃ in industry. It is a kind of high-performance and strong explosive with higher explosive power than TNT. It is often used as booster or mixed with TNT. It was used extensively in the Second World War. It is a long-acting vasodilator and can treat angina pectoris. Pentaerythritol rosin ester can be prepared by the reaction of pentaerythritol and rosin acid. It can be mixed with dry oil to obtain a coating with good hardness, water resistance and weather resistance. It can be used for varnishes, floor inks, etc. An alkyd resin coating can be prepared by esterification polycondensation of pentaerythritol or glycerin with phthalic anhydride and fatty acid. The properties of alkyd resin can be improved by using different kinds and different amounts of fatty acids, making it suitable for various needs of coatings. It is widely used as metal, wood surface coating, for bridges, railways, derricks, housing construction and other commonly used industrial paint and architectural paint. Alkyd resin has developed rapidly since it entered industrial production in 1927 due to its low price, easy availability of raw materials, easy modification, strong adaptability and good comprehensiveness.

P-aminophenol is a fine chemical intermediate commonly used in China. It is used in the dye industry to synthesize weak acid yellow 6G, weak acid light yellow 5g, sulfurized deep blue 3R, sulfurized blue CV, sulfurized brilliant green GB, sulfurized red brown b3r, sulfurized reduced black CLG, etc. In the pharmaceutical industry, it is used in the synthesis of paracetamol, metoprolol, etc. it is also used in the preparation of developer, antioxidant, petroleum additive and other products.

Produced as an inhibitor, an antioxidant, and an intermediate in the synthesis of dyes, motor fuels, and oils; in photographic processing; and naturally in certain plant species, Hydroquinone is a phenol derivative with antioxidant properties that can cause toxicity in several organs, notably the kidney. Used as a topical treatment for skin hyperpigmentation and in various cosmetic products, it is metabolized mainly to glutathione conjugates and forms mutagenic DNA adducts in in-vitro systems.

2,3-dichloropyridine is used as a reagent for preparing substituted 3 - (5-membered heterocyclic carboxyamido) pyridine derivatives for the treatment of autoimmune diseases and inflammatory diseases. The synthesis, crystal structure and biological activity of a new o-aminobenzamide dicarbonamide insecticide were also synthesized in propargyl ether. Chemical properties white powder