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CAS:49755-67-1
Molecular Formula:C13H12I3N3O5
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Unii-3Lgr5S8101; Acide Ioglicique; Ioglicic Acid; Acido Ioglicico; Acidum Ioglicicum; Sh H 200 Ab; 3Lgr5S8101
Brief Introduction
Ioglicic acid is an amidobenzoic acid.
CAS:49763-96-4
Molecular Formula:C14H18O3
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1-(1,3-Benzodioxol-5-Yl)-4,4-Dimethyl-1-Penten-3-Ol; 4,4-Dimethyl-1-(3,4-Methylenedioxyphenyl)-1-Penten-3-Ol; 4,4-Dimethyl-1-[3,4(Methylenedioxy)-Phenyl]-1-Penten-3-Ol,Diacomit; (E)-1-(1,3-Benzodioxol-5-Yl)-4,4-Dimethylpent-1-En-3-Ol; Diacomit; Bcx 2600
Brief Introduction
The action mechanism of stilamyl alcohol (slipantol) is unique. It can not only increase the release of GABA, but also inhibit the activity of some enzymes, so as to increase the blood concentration of other antiepileptic drugs. Stilamyl alcohol (slipantol) was approved in the EU in 2001 for adjuvant treatment of severe infantile epileptic myoclonic seizures.
CAS:497833-27-9
Molecular Formula:C24H27N3O4
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Itf2357; (6-((Diethylamino)Methyl)Naphthalen-2-Yl)Methyl(4-(Hydroxycarbamoyl)Phenyl)Carbamate; Givinostat [Inn]; Ex-5958; Unii-5P60F84Fbh; Italfarmaco; Diethyl-[6-(4-Hydroxycarbamoyl-Phenylcarbamoyloxymethyl)-Naphthalen-2-Yl-Methyl]-Amine; Givinostat Free Base
Brief Introduction
Givinostat is an orally bioavailable hydroxymate inhibitor of histone deacetylase (HDAC) with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. Givinostat inhibits class I and class II HDACs, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. At low, nonapoptotic concentrations, this agent inhibits the production of pro-inflammatory cytokines such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-6 and interferon-gamma. Givinostat has also been shown to activate the intrinsic apoptotic pathway, inducing apoptosis in hepatoma cells and leukemic cells. This agent may also exhibit anti-angiogenic activity, inhibiting the production of angiogenic factors such as IL-6 and vascular endothelial cell growth factor (VEGF) by bone marrow stromal cells.
CAS:499-67-2
Molecular Formula:C16H26N2O3
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Proparacaine; 2-(Diethylamino)Ethyl 3-Amino-4-Propoxybenzoate; Ophthaine; Proximetacainum; Alcaine
Brief Introduction
Proparacaine is a benzoic acid derivative anesthetic agent, with local anesthetic activity. Upon administration, proparacaine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels. This inhibits the sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, increases the threshold for electrical stimulation and results in a loss of sensation.
CAS:50-35-1
Molecular Formula:C13H10N2O4
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Thalomid; 2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione; Sedoval; (+/-)-Thalidomide; N-Phthalylglutamic Acid Imide; 3-Phthalimidoglutarimide; Alpha-Phthalimidoglutarimide; (+-)-Thalidomide; 2,6-Dioxo-3-Phthalimidopiperidine; Thalidomide Celgene; Alpha-N-Phthalylglutaramide; N-(2,6-Dioxo-3-Piperidyl)Phthalimide; Glutarimide, 2-Phthalimido-; N-Phthalyl-Glutaminsaeure-Imid; Alpha-(N-Phthalimido)Glutarimide; 1H-Isoindole-1,3(2H)-Dione, 2-(2,6-Dioxo-3-Piperidinyl)-; 1,3-Dioxo-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline; .Alpha.-N-Phthalylglutaramide; Phthalimide, N-(2,6-Dioxo-3-Piperidyl)-; 2-(2,6-Dioxopiperidin-3-Yl)-1H-Isoindole-1,3(2H)-Dione; 2-(2,6-Dioxopiperidin-3-Yl)-2,3-Dihydro-1H-Isoindole-1,3-Dione; .Alpha.-Phthalimidoglutarimide; 2-(2,6-Dioxo-3-Piperidinyl)-1H-Isoindole-1,3(2H)-Dione
Brief Introduction
Thalidomide is a synthetic glutamate derivative, which is mainly used to treat epilepsy. However, due to its lack of effectiveness, thalidomide was subsequently used as a sleep adjuvant and widely used to stop vomiting during pregnancy. In the early 1960s, thalidomide was reported to cause a large number of infant malformations, which was banned by many countries and withdrawn from the pharmaceutical market. However, scientists did not completely deny thalidomide and continued to conduct in-depth research on it, especially in immunization, anti-inflammatory Gratifying and encouraging results have been obtained in the pharmacology of anti angiogenesis and the clinical treatment of some difficult diseases, so that people have a new understanding of thalidomide.
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