Pharmaceutical Raw Materials

Perindopril is an inhibitor of an enzyme (angiotensin converting enzyme) that converts angiotensin I to angiotensin II. This kind of invertase or kinase is a kind of peptidolytic enzyme. It can convert angiotensin I into angiotensin II, which is used to constrict blood vessels. It can also degrade bradykinin, which is used to dilate blood vessels, into inactive heptapeptide. Inhibition of angiotensin converting enzyme results in a decrease of angiotensin II in plasma, which leads to an increase in plasma renin activity (by inhibiting the negative feedback of renin release) and a decrease in aldosterone secretion. Because angiotensin-converting enzyme inactivates bradykinin, inhibition of angiotensin-converting enzyme can also increase the activity of circulating and local kallikrein kinin system (and thus prostaglandin system). This mechanism may be related to the effect of angiotensin converting enzyme inhibitors on lowering blood pressure, and may also be related to some side effects (such as cough). Perindopril acts through its active metabolite perindoprila.

Succinic anhydride crystallizes in white orthogonal cone and double cone at room temperature. It is slightly pungent, insoluble in water and ether, but soluble in chloroform. This product is the raw material of coating, medicine, synthetic resin and dye. It is used for organic synthesis. It is the raw material of alkyd resin, adhesive resin and anthraquinone dye for coating. The coating made of it has flexibility and water resistance. It can be used in medicine to produce vitamin A and sulfonamides. It can be used in agriculture to produce fungicides, insecticides and plant growth regulators. Succinic anhydride and its derivatives can be used as olefin polymerization catalyst, cross-linking agent of ester polymer condensate, light stabilizer of polymer, ultraviolet absorber, etc., and also as oilfield auxiliary.

Intermediate of piperazine penicillin.

This product has good antibacterial effect on Streptococcus, Streptococcus pneumoniae and Staphylococcus which does not produce penicillin. It has medium antibacterial effect on Enterococcus. Neisseria gonorrhoeae, Neisseria meningitidis, Lolium diphtheriae, Bacillus anthracis, actinomycetes, Streptococcus moniliae, Listeria, leptospira and Treponema pallidum are sensitive to this product. The product also has certain antibacterial activity to Haemophilus influenzae and pertussis bautez, and other gram negative aerobic or facultative anaerobic bacteria have poor sensitivity to the product. This product has good antibacterial effect on Bacillus fusiform, anaerobes of Enterococcus and Pseudomonas melanomycetes, and has poor antibacterial effect on vulnerable Pseudomonas. Penicillin plays a bactericidal role by inhibiting the synthesis of bacterial cell wall.

Mupirocin calcium (dihydrate) is mainly used as antibiotic pharmaceutical raw materials.