Veterinary API

Spectinomycin hydrochloride is produced by Streptomyces. It is an aminoglycoside fast bactericidal antibiotic which is composed of neutral sugar and amino cyclic alcohol glycoside bond. Spectinomycin hydrochloride is a broad-spectrum rapid bactericide, which has strong effect on Escherichia coli, Salmonella, Pasteurella, proteus, hemolytic streptococcus, Streptococcus pneumoniae, and pneumonia; Therefore, it has a good clinical effect on the treatment of infectious diseases caused by these sensitive bacteria. It can inhibit Gram-positive and Gram-negative bacteria. It has strong antibacterial effect on Neisseria gonorrhoeae and good antibacterial activity on Neisseria gonorrhoeae producing B-lactamase. It is a new special drug for gonorrhea.

Monensin, also known as "rumen element", is a substance secreted by the microbial meat Streptomyces cinnamomi. Monensin sodium salt can affect the ion balance of insects and cause the rupture and death of insects. It can also control the proportion of volatile fatty acids in rumen, reduce the degradation of protein in rumen and reduce the consumption of feed dry matter, It is widely added to the feed of ruminants to prevent and control coccidiosis of chickens, lambs, calves and rabbits and promote the growth of ruminants.

Pentachlorosalamide, also known as hydroxychlorosalamide, hydroxychlorosalaniline and hydroxychlorozamide, is the preferred drug for clinical anti worm infection. It has the excellent characteristics of broad spectrum, low toxicity and low residue. As a chemical synthetic drug against worm infection, peclosamide has the excellent characteristics of broad spectrum, low toxicity and low residue. It has a significant effect in the treatment of trematode, tapeworm and other worm infections, and there is no report of drug resistance so far. It is the first choice for clinical anti worm infection.

Since probenecid is almost insoluble in water, when combined with penicillins for injection to form a compound injection, probenecid needs to be transformed into water-soluble salts, usually into water-soluble probenecid sodium. Probenecid sodium and probenecid potassium and β- The compound injection composed of lactam antibiotics and its application can reduce the content in the compound β- The dosage of lactam antibiotics can effectively reduce the occurrence and development of bacterial drug resistance caused by ultra-high dose antibiotics; It can also save antibiotic resources and reduce the abuse of antibiotics; Probenecid sodium (potassium) and β- Lactam antibiotics include penicillin antibiotics and cephalosporin antibiotics, which are composed of powder injection K and lyophilized powder injection β- Lactam antibiotics were injected intravenously or intravenously at the same time. Can effectively extend β- The half-life (T1 / 2) of lactam antibiotics can increase the area under the curve (AUC), eliminate the hemolysis of probenecid sodium (potassium), protect the safety of probenecid sodium (potassium) in human body, and can enter human body safely and effectively as a new compound preparation through intravenous route; By probenecid sodium (potassium) and β- Because the compound injection composed of lactam antibiotics directly enters the blood circulation and is completely absorbed by the human body, it can quickly reach the peak, act quickly and have more remarkable curative effect.

Alfaxalone (INN, JAN), also known as alphaxalone or alphaxolone (BAN), is a neuroactive steroid and general anaesthetic. It is used in veterinary practice under the trade name Alfaxan, and is licensed for use in both dogs and cats. Along with alfadolone, it is also one of the constituents of anesthetic drug mixture althesin. Unlike some of its predecessors alfaxalone is not associated with histamine release and anaphylaxis.; A study 1987 found the primary mechanism for the anaesthetic action of alfaxalone to be modulation of neuronal cell membrane chloride ion transport, induced by binding of alfaxalone to GABAA cell surface receptors. A 1994 study found that alfaxalone binds to a different region of this receptor than the benzodiazepines. These benzodiazepine-insensitive GABAA receptors are located extrasynaptically and are responsible for tonic inhibition. The occurrence of tonic GABAA inhibition coincides with the expression of relatively rare receptor subunits, particularly the α4, α6, and δ subunits, and as a rule of thumb, δ subunit-containing receptors are extrasynaptic. Alfaxalone is metabolised rapidly in the liver. It has a very short plasma elimination half-life in dogs and cats.